Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review
Abstract Subcutaneous fat necrosis (SCFN) is a noninfectious panniculitis that occurs in term infants who experience significant distress in the 1st weeks of life, including hypoxic ischemic encephalopathy (HIE). Since the introduction of therapeutic hypothermia for HIE, there have been a few publis...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2014-11-01
|
| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1395987 |
| _version_ | 1818979135473582080 |
|---|---|
| author | Veronica Mugarab Samedi Kamran Yusuf Wendy Yee Hala Obaid Essa Hamdan Al Awad |
| author_facet | Veronica Mugarab Samedi Kamran Yusuf Wendy Yee Hala Obaid Essa Hamdan Al Awad |
| author_sort | Veronica Mugarab Samedi |
| collection | DOAJ |
| description | Abstract
Subcutaneous fat necrosis (SCFN) is a noninfectious panniculitis that occurs in term infants who experience significant distress in the 1st weeks of life, including hypoxic ischemic encephalopathy (HIE). Since the introduction of therapeutic hypothermia for HIE, there have been a few published case reports of SCFN, following this modality of treatment. Although, most cases of SCFN resolve spontaneously, SCFN may be associated with hypercalcemia, which may sometimes reach dangerous levels. Approaches used for the management of this potentially life-threatening condition, include hyperhydration, calciuric diuretics, corticosteroids, and in more resistant cases pamidronate, a bisphosphonate. We report our experience on the use of pamidronate in two cases of severe hypercalcemia associated with SCFN following therapeutic hypothermia for HIE. We believe that with increasing use of therapeutic hypothermia for HIE, clinicians are likely to encounter this condition more frequently. |
| first_indexed | 2024-12-20T16:54:43Z |
| format | Article |
| id | doaj.art-33c2d5ada9a2408d84003e5b53c10cde |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-20T16:54:43Z |
| publishDate | 2014-11-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-33c2d5ada9a2408d84003e5b53c10cde2022-12-21T19:32:45ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052014-11-010402e93e9610.1055/s-0034-1395987Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature ReviewVeronica Mugarab Samedi0Kamran Yusuf1Wendy Yee2Hala Obaid3Essa Hamdan Al Awad4Section of Neonatology, Peter Lougheed Centre, Calgary, Alberta, CanadaSection of Neonatology, University of Calgary, Calgary, Alberta, CanadaSection of Neonatology, University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaSection of Neonatology, Peter Lougheed Centre, Calgary, Alberta, CanadaAbstract Subcutaneous fat necrosis (SCFN) is a noninfectious panniculitis that occurs in term infants who experience significant distress in the 1st weeks of life, including hypoxic ischemic encephalopathy (HIE). Since the introduction of therapeutic hypothermia for HIE, there have been a few published case reports of SCFN, following this modality of treatment. Although, most cases of SCFN resolve spontaneously, SCFN may be associated with hypercalcemia, which may sometimes reach dangerous levels. Approaches used for the management of this potentially life-threatening condition, include hyperhydration, calciuric diuretics, corticosteroids, and in more resistant cases pamidronate, a bisphosphonate. We report our experience on the use of pamidronate in two cases of severe hypercalcemia associated with SCFN following therapeutic hypothermia for HIE. We believe that with increasing use of therapeutic hypothermia for HIE, clinicians are likely to encounter this condition more frequently.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1395987hypercalcemiatherapeutic hypothermianewbornpamidronatesubcutaneous fat necrosis |
| spellingShingle | Veronica Mugarab Samedi Kamran Yusuf Wendy Yee Hala Obaid Essa Hamdan Al Awad Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review American Journal of Perinatology Reports hypercalcemia therapeutic hypothermia newborn pamidronate subcutaneous fat necrosis |
| title | Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review |
| title_full | Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review |
| title_fullStr | Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review |
| title_full_unstemmed | Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review |
| title_short | Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review |
| title_sort | neonatal hypercalcemia secondary to subcutaneous fat necrosis successfully treated with pamidronate a case series and literature review |
| topic | hypercalcemia therapeutic hypothermia newborn pamidronate subcutaneous fat necrosis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1395987 |
| work_keys_str_mv | AT veronicamugarabsamedi neonatalhypercalcemiasecondarytosubcutaneousfatnecrosissuccessfullytreatedwithpamidronateacaseseriesandliteraturereview AT kamranyusuf neonatalhypercalcemiasecondarytosubcutaneousfatnecrosissuccessfullytreatedwithpamidronateacaseseriesandliteraturereview AT wendyyee neonatalhypercalcemiasecondarytosubcutaneousfatnecrosissuccessfullytreatedwithpamidronateacaseseriesandliteraturereview AT halaobaid neonatalhypercalcemiasecondarytosubcutaneousfatnecrosissuccessfullytreatedwithpamidronateacaseseriesandliteraturereview AT essahamdanalawad neonatalhypercalcemiasecondarytosubcutaneousfatnecrosissuccessfullytreatedwithpamidronateacaseseriesandliteraturereview |