Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics
Various bacterial pathogens are responsible for nosocomial infections resulting in critical pathophysiological conditions, mortality, and morbidity. Most of the bacterial infections are associated with biofilm formation, which is resistant to the available antimicrobial drugs. As a result, novel bac...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2020.610968/full |
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| author | Bansi Ranpariya Gayatri Salunke Gayatri Salunke Srikanta Karmakar Kaushik Babiya Santosh Sutar Narendra Kadoo Narendra Kadoo Pathik Kumbhakar Sougata Ghosh |
| author_facet | Bansi Ranpariya Gayatri Salunke Gayatri Salunke Srikanta Karmakar Kaushik Babiya Santosh Sutar Narendra Kadoo Narendra Kadoo Pathik Kumbhakar Sougata Ghosh |
| author_sort | Bansi Ranpariya |
| collection | DOAJ |
| description | Various bacterial pathogens are responsible for nosocomial infections resulting in critical pathophysiological conditions, mortality, and morbidity. Most of the bacterial infections are associated with biofilm formation, which is resistant to the available antimicrobial drugs. As a result, novel bactericidal agents need to be fabricated, which can effectively combat the biofilm-associated bacterial infections. Herein, for the first time we report the antimicrobial and antibiofilm properties of silver-platinum nanohybrids (AgPtNHs), silver nanoparticles (AgNPs), and platinum nanoparticles (PtNPs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The AgPtNHs were synthesized by a green route using Dioscorea bulbifera tuber extract at 100°C for 5 h. The AgPtNHs ranged in size from 20 to 80 nm, with an average of ∼59 nm. AgNPs, PtNPs, and AgPtNHs showed a zeta potential of −14.46, −1.09, and −11.39 mV, respectively. High antimicrobial activity was observed against P. aeruginosa and S. aureus and AgPtNHs exhibited potent antimicrobial synergy in combination with antibiotics such as streptomycin, rifampicin, chloramphenicol, novobiocin, and ampicillin up to variable degrees. Interestingly, AgPtNHs could inhibit bacterial biofilm formation significantly. Hence, co-administration of AgPtNHs and antibiotics may serve as a powerful strategy to treat bacterial infections. |
| first_indexed | 2024-12-20T04:04:27Z |
| format | Article |
| id | doaj.art-33c3b39960e74b6b9ba0a300fa8953a8 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T04:04:27Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-33c3b39960e74b6b9ba0a300fa8953a82022-12-21T19:54:04ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-02-011110.3389/fmicb.2020.610968610968Antimicrobial Synergy of Silver-Platinum Nanohybrids With AntibioticsBansi Ranpariya0Gayatri Salunke1Gayatri Salunke2Srikanta Karmakar3Kaushik Babiya4Santosh Sutar5Narendra Kadoo6Narendra Kadoo7Pathik Kumbhakar8Sougata Ghosh9Department of Microbiology, School of Science, RK University, Rajkot, IndiaBiochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, IndiaAcademy of Scientific and Innovative Research, Ghaziabad, IndiaNanoscience Laboratory, Department of Physics, National Institute of Technology Durgapur, Durgapur, IndiaDepartment of Microbiology, School of Science, RK University, Rajkot, IndiaYashwantrao Chavan School of Rural Development, Shivaji University, Kolhapur, IndiaBiochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, IndiaAcademy of Scientific and Innovative Research, Ghaziabad, IndiaNanoscience Laboratory, Department of Physics, National Institute of Technology Durgapur, Durgapur, IndiaDepartment of Microbiology, School of Science, RK University, Rajkot, IndiaVarious bacterial pathogens are responsible for nosocomial infections resulting in critical pathophysiological conditions, mortality, and morbidity. Most of the bacterial infections are associated with biofilm formation, which is resistant to the available antimicrobial drugs. As a result, novel bactericidal agents need to be fabricated, which can effectively combat the biofilm-associated bacterial infections. Herein, for the first time we report the antimicrobial and antibiofilm properties of silver-platinum nanohybrids (AgPtNHs), silver nanoparticles (AgNPs), and platinum nanoparticles (PtNPs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The AgPtNHs were synthesized by a green route using Dioscorea bulbifera tuber extract at 100°C for 5 h. The AgPtNHs ranged in size from 20 to 80 nm, with an average of ∼59 nm. AgNPs, PtNPs, and AgPtNHs showed a zeta potential of −14.46, −1.09, and −11.39 mV, respectively. High antimicrobial activity was observed against P. aeruginosa and S. aureus and AgPtNHs exhibited potent antimicrobial synergy in combination with antibiotics such as streptomycin, rifampicin, chloramphenicol, novobiocin, and ampicillin up to variable degrees. Interestingly, AgPtNHs could inhibit bacterial biofilm formation significantly. Hence, co-administration of AgPtNHs and antibiotics may serve as a powerful strategy to treat bacterial infections.https://www.frontiersin.org/articles/10.3389/fmicb.2020.610968/fullbiogenic synthesissilver-platinum nanohybridscharacterizationantimicrobial synergyantibiofilm |
| spellingShingle | Bansi Ranpariya Gayatri Salunke Gayatri Salunke Srikanta Karmakar Kaushik Babiya Santosh Sutar Narendra Kadoo Narendra Kadoo Pathik Kumbhakar Sougata Ghosh Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics Frontiers in Microbiology biogenic synthesis silver-platinum nanohybrids characterization antimicrobial synergy antibiofilm |
| title | Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics |
| title_full | Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics |
| title_fullStr | Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics |
| title_full_unstemmed | Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics |
| title_short | Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics |
| title_sort | antimicrobial synergy of silver platinum nanohybrids with antibiotics |
| topic | biogenic synthesis silver-platinum nanohybrids characterization antimicrobial synergy antibiofilm |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2020.610968/full |
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