TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart Disease
Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may form homo or heterotetrameric ion channels, and the...
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MDPI AG
2020-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/1/173 |
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| author | Débora Falcón Isabel Galeano-Otero Marta Martín-Bórnez María Fernández-Velasco Isabel Gallardo-Castillo Juan A. Rosado Antonio Ordóñez Tarik Smani |
| author_facet | Débora Falcón Isabel Galeano-Otero Marta Martín-Bórnez María Fernández-Velasco Isabel Gallardo-Castillo Juan A. Rosado Antonio Ordóñez Tarik Smani |
| author_sort | Débora Falcón |
| collection | DOAJ |
| description | Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may form homo or heterotetrameric ion channels, and they can associate with other membrane receptors and ion channels to regulate intracellular calcium concentration. Dysfunctions of TRPC channels are involved in many types of cardiovascular diseases. Significant increase in the expression of different TRPC isoforms was observed in different animal models of heart infarcts and in vitro experimental models of ischemia and reperfusion. TRPC channel-mediated increase of the intracellular Ca<sup>2+</sup> concentration seems to be required for the activation of the signaling pathway that plays minor roles in the healthy heart, but they are more relevant for cardiac responses to ischemia, such as the activation of different factors of transcription and cardiac hypertrophy, fibrosis, and angiogenesis. In this review, we highlight the current knowledge regarding TRPC implication in different cellular processes related to ischemia and reperfusion and to heart infarction. |
| first_indexed | 2024-03-12T07:06:56Z |
| format | Article |
| id | doaj.art-33c46d8de08e416994dd7849f8a2d236 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:06:56Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-33c46d8de08e416994dd7849f8a2d2362023-09-02T23:22:46ZengMDPI AGCells2073-44092020-01-019117310.3390/cells9010173cells9010173TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart DiseaseDébora Falcón0Isabel Galeano-Otero1Marta Martín-Bórnez2María Fernández-Velasco3Isabel Gallardo-Castillo4Juan A. Rosado5Antonio Ordóñez6Tarik Smani7Department of Medical Physiology and Biophysics, Institute of Biomedicine of Seville, University of Seville, 41013 Seville, SpainDepartment of Medical Physiology and Biophysics, Institute of Biomedicine of Seville, University of Seville, 41013 Seville, SpainDepartment of Medical Physiology and Biophysics, Institute of Biomedicine of Seville, University of Seville, 41013 Seville, SpainBiomedical Research Networking Centers of Cardiovascular Diseases (CIBERCV), 28029 Madrid, SpainDepartment of Stomatology, School of Dentistry, University of Seville, 41009 Seville, SpainDepartment of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainBiomedical Research Networking Centers of Cardiovascular Diseases (CIBERCV), 28029 Madrid, SpainDepartment of Medical Physiology and Biophysics, Institute of Biomedicine of Seville, University of Seville, 41013 Seville, SpainTransient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may form homo or heterotetrameric ion channels, and they can associate with other membrane receptors and ion channels to regulate intracellular calcium concentration. Dysfunctions of TRPC channels are involved in many types of cardiovascular diseases. Significant increase in the expression of different TRPC isoforms was observed in different animal models of heart infarcts and in vitro experimental models of ischemia and reperfusion. TRPC channel-mediated increase of the intracellular Ca<sup>2+</sup> concentration seems to be required for the activation of the signaling pathway that plays minor roles in the healthy heart, but they are more relevant for cardiac responses to ischemia, such as the activation of different factors of transcription and cardiac hypertrophy, fibrosis, and angiogenesis. In this review, we highlight the current knowledge regarding TRPC implication in different cellular processes related to ischemia and reperfusion and to heart infarction.https://www.mdpi.com/2073-4409/9/1/173trpc channelca<sup>2+</sup> entrycardiac infarctioncardiac repair |
| spellingShingle | Débora Falcón Isabel Galeano-Otero Marta Martín-Bórnez María Fernández-Velasco Isabel Gallardo-Castillo Juan A. Rosado Antonio Ordóñez Tarik Smani TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart Disease Cells trpc channel ca<sup>2+</sup> entry cardiac infarction cardiac repair |
| title | TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart Disease |
| title_full | TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart Disease |
| title_fullStr | TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart Disease |
| title_full_unstemmed | TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart Disease |
| title_short | TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart Disease |
| title_sort | trpc channels dysregulation and ca sup 2 sup mishandling in ischemic heart disease |
| topic | trpc channel ca<sup>2+</sup> entry cardiac infarction cardiac repair |
| url | https://www.mdpi.com/2073-4409/9/1/173 |
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