<i>MTOR</i> Variation Related to Heat Resistance of Chinese Cattle
With the inexorable rise of global temperature, heat stress deserves more and more attention in livestock agriculture. Previous studies have shown that the mechanistic target of rapamycin (<i>MTOR</i>) (NC_037343.1:c.2062G>C) gene contributes to the repair of DNA damage repair and...
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| Format: | Article |
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MDPI AG
2019-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/9/11/915 |
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| author | Qingqing Ning Kaixing Qu Quratulain Hanif Yutang Jia Haijian Cheng Jicai Zhang Ningbo Chen Hong Chen Bizhi Huang Chuzhao Lei |
| author_facet | Qingqing Ning Kaixing Qu Quratulain Hanif Yutang Jia Haijian Cheng Jicai Zhang Ningbo Chen Hong Chen Bizhi Huang Chuzhao Lei |
| author_sort | Qingqing Ning |
| collection | DOAJ |
| description | With the inexorable rise of global temperature, heat stress deserves more and more attention in livestock agriculture. Previous studies have shown that the mechanistic target of rapamycin (<i>MTOR</i>) (NC_037343.1:c.2062G>C) gene contributes to the repair of DNA damage repair and is associated with the adaptation of camels in dry and hot environments. However, it is unknown whether this mutation is related to the heat tolerance of Chinese cattle. In this study, PCR and sequencing were used to type the mutation locus in 1030 individuals of 37 cattle breeds. The analysis results showed that the frequency of G allele of the locus gradually diminished from the northern group to the southern group of native Chinese cattle, whereas the frequency of the C allele showed an opposite pattern, displaying a significant geographical difference across native Chinese cattle breeds. Additionally, an analysis of the locus in Chinese indigenous cattle revealed that this SNP was significantly associated with mean annual temperature (T), relative humidity (RH) and temperature humidity index (THI) (<i>p</i> < 0.01), suggesting that cattle with C allele was distributed in regions with higher T, RH and THI. In conclusion, this study proved that the mutation of <i>MTOR</i> gene in Chinese cattle could be associated with the heat tolerance. |
| first_indexed | 2024-12-10T08:32:15Z |
| format | Article |
| id | doaj.art-33c4e4d026da40a594f53ed2c9f63f77 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-12-10T08:32:15Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-33c4e4d026da40a594f53ed2c9f63f772022-12-22T01:56:04ZengMDPI AGAnimals2076-26152019-11-0191191510.3390/ani9110915ani9110915<i>MTOR</i> Variation Related to Heat Resistance of Chinese CattleQingqing Ning0Kaixing Qu1Quratulain Hanif2Yutang Jia3Haijian Cheng4Jicai Zhang5Ningbo Chen6Hong Chen7Bizhi Huang8Chuzhao Lei9Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaYunnan Academy of Grassland and Animal Science, Kunming 650212, ChinaNational Institute for Biotechnology and Genetic Engineering, Pakistan Institute of Engineering and Applied Sciences, Faisalabad 577, PakistanInstitute of Animal Science and Veterinary Medicine, Anhui Academy of Agriculture Science, Hefei 230001, ChinaInstitute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, ChinaYunnan Academy of Grassland and Animal Science, Kunming 650212, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaYunnan Academy of Grassland and Animal Science, Kunming 650212, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaWith the inexorable rise of global temperature, heat stress deserves more and more attention in livestock agriculture. Previous studies have shown that the mechanistic target of rapamycin (<i>MTOR</i>) (NC_037343.1:c.2062G>C) gene contributes to the repair of DNA damage repair and is associated with the adaptation of camels in dry and hot environments. However, it is unknown whether this mutation is related to the heat tolerance of Chinese cattle. In this study, PCR and sequencing were used to type the mutation locus in 1030 individuals of 37 cattle breeds. The analysis results showed that the frequency of G allele of the locus gradually diminished from the northern group to the southern group of native Chinese cattle, whereas the frequency of the C allele showed an opposite pattern, displaying a significant geographical difference across native Chinese cattle breeds. Additionally, an analysis of the locus in Chinese indigenous cattle revealed that this SNP was significantly associated with mean annual temperature (T), relative humidity (RH) and temperature humidity index (THI) (<i>p</i> < 0.01), suggesting that cattle with C allele was distributed in regions with higher T, RH and THI. In conclusion, this study proved that the mutation of <i>MTOR</i> gene in Chinese cattle could be associated with the heat tolerance.https://www.mdpi.com/2076-2615/9/11/915chinese cattle<i>mtor</i> genevariationheat toleranceassociation |
| spellingShingle | Qingqing Ning Kaixing Qu Quratulain Hanif Yutang Jia Haijian Cheng Jicai Zhang Ningbo Chen Hong Chen Bizhi Huang Chuzhao Lei <i>MTOR</i> Variation Related to Heat Resistance of Chinese Cattle Animals chinese cattle <i>mtor</i> gene variation heat tolerance association |
| title | <i>MTOR</i> Variation Related to Heat Resistance of Chinese Cattle |
| title_full | <i>MTOR</i> Variation Related to Heat Resistance of Chinese Cattle |
| title_fullStr | <i>MTOR</i> Variation Related to Heat Resistance of Chinese Cattle |
| title_full_unstemmed | <i>MTOR</i> Variation Related to Heat Resistance of Chinese Cattle |
| title_short | <i>MTOR</i> Variation Related to Heat Resistance of Chinese Cattle |
| title_sort | i mtor i variation related to heat resistance of chinese cattle |
| topic | chinese cattle <i>mtor</i> gene variation heat tolerance association |
| url | https://www.mdpi.com/2076-2615/9/11/915 |
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