Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling

Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling

Glucose-6-phosphate dehydrogenase (G6PD)-deficient cells are highly susceptible to viral infection. This study examined the mechanism underlying this phenomenon by measuring the expression of antiviral genes—tumor necrosis factor alpha (TNF-α) and GTPase myxovirus resistance 1 (MX1)—in G6PD-knockdow...

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Bibliographic Details
Main Authors: Yi-Hsuan Wu, Daniel Tsun-Yee Chiu, Hsin-Ru Lin, Hsiang-Yu Tang, Mei-Ling Cheng, Hung-Yao Ho
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Viruses
Subjects:
G6PD
NADPH
coronavirus
enterovirus
antiviral response
HSCARG
Online Access:http://www.mdpi.com/1999-4915/7/12/2966

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