Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective
Since the pioneering work of Vallet-Regí’s group on the design and synthesis of mesoporous silica-based materials with therapeutic applications, during the last 15 years, the potential use of mesoporous silica nanostructured materials as drug delivery vehicles has been extensively explored. The vers...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2332 |
| _version_ | 1797624384069828608 |
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| author | Diana Díaz-García Sanjiv Prashar Santiago Gómez-Ruiz |
| author_facet | Diana Díaz-García Sanjiv Prashar Santiago Gómez-Ruiz |
| author_sort | Diana Díaz-García |
| collection | DOAJ |
| description | Since the pioneering work of Vallet-Regí’s group on the design and synthesis of mesoporous silica-based materials with therapeutic applications, during the last 15 years, the potential use of mesoporous silica nanostructured materials as drug delivery vehicles has been extensively explored. The versatility of these materials allows the design of a wide variety of platforms that can incorporate numerous agents of interest (fluorophores, proteins, drugs, etc.) in a single scaffold. However, the use of these systems loaded with metallodrugs as cytotoxic agents against different diseases and with distinct therapeutic targets has been studied to a much lesser extent. This review will focus on the work carried out in this field, highlighting both the pioneering and recent contributions of Spanish groups that have synthesized a wide variety of systems based on titanium, tin, ruthenium, copper and silver complexes supported onto nanostructured silica. In addition, this article will also discuss the importance of the structural features of the systems for evaluating and modulating their therapeutic properties. Finally, the most interesting results obtained in the study of the potential therapeutic application of these metallodrug-functionalized silica-based materials against cancer and bacteria will be described, paying special attention to preclinical trials in vivo. |
| first_indexed | 2024-03-11T09:41:38Z |
| format | Article |
| id | doaj.art-33c53f525364451fb07210ebbaeef209 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:41:38Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-33c53f525364451fb07210ebbaeef2092023-11-16T16:55:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243233210.3390/ijms24032332Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish PerspectiveDiana Díaz-García0Sanjiv Prashar1Santiago Gómez-Ruiz2COMET-NANO Group, Departamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, C/Tulipán s/n, E-28933 Móstoles, SpainCOMET-NANO Group, Departamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, C/Tulipán s/n, E-28933 Móstoles, SpainCOMET-NANO Group, Departamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, C/Tulipán s/n, E-28933 Móstoles, SpainSince the pioneering work of Vallet-Regí’s group on the design and synthesis of mesoporous silica-based materials with therapeutic applications, during the last 15 years, the potential use of mesoporous silica nanostructured materials as drug delivery vehicles has been extensively explored. The versatility of these materials allows the design of a wide variety of platforms that can incorporate numerous agents of interest (fluorophores, proteins, drugs, etc.) in a single scaffold. However, the use of these systems loaded with metallodrugs as cytotoxic agents against different diseases and with distinct therapeutic targets has been studied to a much lesser extent. This review will focus on the work carried out in this field, highlighting both the pioneering and recent contributions of Spanish groups that have synthesized a wide variety of systems based on titanium, tin, ruthenium, copper and silver complexes supported onto nanostructured silica. In addition, this article will also discuss the importance of the structural features of the systems for evaluating and modulating their therapeutic properties. Finally, the most interesting results obtained in the study of the potential therapeutic application of these metallodrug-functionalized silica-based materials against cancer and bacteria will be described, paying special attention to preclinical trials in vivo.https://www.mdpi.com/1422-0067/24/3/2332metal complexesnanostructured materialssilicatherapycancerantibacterial |
| spellingShingle | Diana Díaz-García Sanjiv Prashar Santiago Gómez-Ruiz Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective International Journal of Molecular Sciences metal complexes nanostructured materials silica therapy cancer antibacterial |
| title | Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective |
| title_full | Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective |
| title_fullStr | Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective |
| title_full_unstemmed | Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective |
| title_short | Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective |
| title_sort | biological use of nanostructured silica based materials functionalized with metallodrugs the spanish perspective |
| topic | metal complexes nanostructured materials silica therapy cancer antibacterial |
| url | https://www.mdpi.com/1422-0067/24/3/2332 |
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