A collagen glucosyltransferase drives lung adenocarcinoma progression in mice
Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01982-w |
| _version_ | 1818845431122100224 |
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| author | Hou-Fu Guo Neus Bota-Rabassedas Masahiko Terajima B. Leticia Rodriguez Don L. Gibbons Yulong Chen Priyam Banerjee Chi-Lin Tsai Xiaochao Tan Xin Liu Jiang Yu Michal Tokmina-Roszyk Roma Stawikowska Gregg B. Fields Mitchell D. Miller Xiaoyan Wang Juhoon Lee Kevin N. Dalby Chad J. Creighton George N. Phillips John A. Tainer Mitsuo Yamauchi Jonathan M. Kurie |
| author_facet | Hou-Fu Guo Neus Bota-Rabassedas Masahiko Terajima B. Leticia Rodriguez Don L. Gibbons Yulong Chen Priyam Banerjee Chi-Lin Tsai Xiaochao Tan Xin Liu Jiang Yu Michal Tokmina-Roszyk Roma Stawikowska Gregg B. Fields Mitchell D. Miller Xiaoyan Wang Juhoon Lee Kevin N. Dalby Chad J. Creighton George N. Phillips John A. Tainer Mitsuo Yamauchi Jonathan M. Kurie |
| author_sort | Hou-Fu Guo |
| collection | DOAJ |
| description | Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression. |
| first_indexed | 2024-12-19T05:29:33Z |
| format | Article |
| id | doaj.art-33c609a5058f4848b50950a0e6133563 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T05:29:33Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-33c609a5058f4848b50950a0e61335632022-12-21T20:34:16ZengNature PortfolioCommunications Biology2399-36422021-04-014111010.1038/s42003-021-01982-wA collagen glucosyltransferase drives lung adenocarcinoma progression in miceHou-Fu Guo0Neus Bota-Rabassedas1Masahiko Terajima2B. Leticia Rodriguez3Don L. Gibbons4Yulong Chen5Priyam Banerjee6Chi-Lin Tsai7Xiaochao Tan8Xin Liu9Jiang Yu10Michal Tokmina-Roszyk11Roma Stawikowska12Gregg B. Fields13Mitchell D. Miller14Xiaoyan Wang15Juhoon Lee16Kevin N. Dalby17Chad J. Creighton18George N. Phillips19John A. Tainer20Mitsuo Yamauchi21Jonathan M. Kurie22Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel HillDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterInstitute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic UniversityInstitute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic UniversityInstitute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic UniversityDepartment of Biosciences, Rice UniversityDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDivision of Medicinal Chemistry, Targeted Therapeutic Drug Discovery and Development Program, College of Pharmacy, The University of Texas at AustinDivision of Medicinal Chemistry, Targeted Therapeutic Drug Discovery and Development Program, College of Pharmacy, The University of Texas at AustinDepartment of Medicine, Dan L. Duncan Cancer Center, Baylor College of MedicineDepartment of Biosciences, Rice UniversityDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel HillDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterGuo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.https://doi.org/10.1038/s42003-021-01982-w |
| spellingShingle | Hou-Fu Guo Neus Bota-Rabassedas Masahiko Terajima B. Leticia Rodriguez Don L. Gibbons Yulong Chen Priyam Banerjee Chi-Lin Tsai Xiaochao Tan Xin Liu Jiang Yu Michal Tokmina-Roszyk Roma Stawikowska Gregg B. Fields Mitchell D. Miller Xiaoyan Wang Juhoon Lee Kevin N. Dalby Chad J. Creighton George N. Phillips John A. Tainer Mitsuo Yamauchi Jonathan M. Kurie A collagen glucosyltransferase drives lung adenocarcinoma progression in mice Communications Biology |
| title | A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_full | A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_fullStr | A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_full_unstemmed | A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_short | A collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| title_sort | collagen glucosyltransferase drives lung adenocarcinoma progression in mice |
| url | https://doi.org/10.1038/s42003-021-01982-w |
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