Calreticulin: Roles in Cell-Surface Protein Expression
In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane. Calreticulin is a multi-functional chaperone protein inv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-09-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2077-0375/4/3/630 |
| _version_ | 1827843980032737280 |
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| author | Yue Jiang Sandeepa Dey Hiroaki Matsunami |
| author_facet | Yue Jiang Sandeepa Dey Hiroaki Matsunami |
| author_sort | Yue Jiang |
| collection | DOAJ |
| description | In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane. Calreticulin is a multi-functional chaperone protein involved in protein folding, maturation, and trafficking. However, evidence has been accumulating that calreticulin can also negatively regulate the surface expression of certain receptors and channels. In these instances, depletion of calreticulin enhances cell-surface expression and function. In this review, we discuss the role of calreticulin with a focus on its negative effects on the expression of cell-surface proteins. |
| first_indexed | 2024-03-12T08:34:40Z |
| format | Article |
| id | doaj.art-33c63c285f4b4589a33ae939629289bf |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-12T08:34:40Z |
| publishDate | 2014-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-33c63c285f4b4589a33ae939629289bf2023-09-02T17:21:55ZengMDPI AGMembranes2077-03752014-09-014363064110.3390/membranes4030630membranes4030630Calreticulin: Roles in Cell-Surface Protein ExpressionYue Jiang0Sandeepa Dey1Hiroaki Matsunami2Department of Molecular Genetics and Microbiology, University Program of Genetics and Genomics, Duke University Medical Center, Durham, NC 27710, USADepartment of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USADepartment of Molecular Genetics and Microbiology, University Program of Genetics and Genomics, Duke University Medical Center, Durham, NC 27710, USAIn order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane. Calreticulin is a multi-functional chaperone protein involved in protein folding, maturation, and trafficking. However, evidence has been accumulating that calreticulin can also negatively regulate the surface expression of certain receptors and channels. In these instances, depletion of calreticulin enhances cell-surface expression and function. In this review, we discuss the role of calreticulin with a focus on its negative effects on the expression of cell-surface proteins.http://www.mdpi.com/2077-0375/4/3/630calreticulincalreticulin4calnexinendoplasmic reticulumchaperonetraffickingreceptorchannelretentionvomeronasalV2RCFTR |
| spellingShingle | Yue Jiang Sandeepa Dey Hiroaki Matsunami Calreticulin: Roles in Cell-Surface Protein Expression Membranes calreticulin calreticulin4 calnexin endoplasmic reticulum chaperone trafficking receptor channel retention vomeronasal V2R CFTR |
| title | Calreticulin: Roles in Cell-Surface Protein Expression |
| title_full | Calreticulin: Roles in Cell-Surface Protein Expression |
| title_fullStr | Calreticulin: Roles in Cell-Surface Protein Expression |
| title_full_unstemmed | Calreticulin: Roles in Cell-Surface Protein Expression |
| title_short | Calreticulin: Roles in Cell-Surface Protein Expression |
| title_sort | calreticulin roles in cell surface protein expression |
| topic | calreticulin calreticulin4 calnexin endoplasmic reticulum chaperone trafficking receptor channel retention vomeronasal V2R CFTR |
| url | http://www.mdpi.com/2077-0375/4/3/630 |
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