Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus

Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus

Abstract Background Interferon-α (IFN-α) is increased and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are the main producer of IFN-α, but their IFN-α producing capacity has been shown to be unchanged or reduced when stimulate...

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Bibliographic Details
Main Authors: Goh Murayama, Nanako Furusawa, Asako Chiba, Ken Yamaji, Naoto Tamura, Sachiko Miyake
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Arthritis Research & Therapy
Subjects:
Systemic lupus erythematosus
Toll-like receptor
Interferon-α
Plasmacytoid dendritic cells
Online Access:http://link.springer.com/article/10.1186/s13075-017-1441-7

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