ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.
Bibliographic Details
| Main Authors: |
Yan Gu,
Yanrong Chen,
Lai Wei,
Shuang Wu,
Kaicheng Shen,
Chengxiang Liu,
Yan Dong,
Yang Zhao,
Yue Zhang,
Chi Zhang,
Wenling Zheng,
Jiangyi He,
Yunlong Wang,
Yifei Li,
Xiaoxin Zhao,
Hongwei Wang,
Jun Tan,
Liting Wang,
Qi Zhou,
Ganfeng Xie,
Houjie Liang,
Juanjuan Ou |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-26967-5
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