ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation

ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation

This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.

Detaylı Bibliyografya
Asıl Yazarlar: Yan Gu, Yanrong Chen, Lai Wei, Shuang Wu, Kaicheng Shen, Chengxiang Liu, Yan Dong, Yang Zhao, Yue Zhang, Chi Zhang, Wenling Zheng, Jiangyi He, Yunlong Wang, Yifei Li, Xiaoxin Zhao, Hongwei Wang, Jun Tan, Liting Wang, Qi Zhou, Ganfeng Xie, Houjie Liang, Juanjuan Ou
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Nature Portfolio 2021-11-01
Seri Bilgileri:Nature Communications
Online Erişim:https://doi.org/10.1038/s41467-021-26967-5

Internet

https://doi.org/10.1038/s41467-021-26967-5

Benzer Materyaller