Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain
The mechanisms underlying selective serotonin reuptake inhibitor (SSRI) use during pregnancy as a major autism risk factor are unclear. Here, brain neurochemical changes following fluoxetine exposure and in an autism model were compared to determine the effects on autism risk. The study was performe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/2/310 |
| _version_ | 1797619291775827968 |
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| author | Ramesa Shafi Bhat Mona Alonazi Sooad Al-Daihan Afaf El-Ansary |
| author_facet | Ramesa Shafi Bhat Mona Alonazi Sooad Al-Daihan Afaf El-Ansary |
| author_sort | Ramesa Shafi Bhat |
| collection | DOAJ |
| description | The mechanisms underlying selective serotonin reuptake inhibitor (SSRI) use during pregnancy as a major autism risk factor are unclear. Here, brain neurochemical changes following fluoxetine exposure and in an autism model were compared to determine the effects on autism risk. The study was performed on neonatal male western albino rats which were divided into Groups one (control), two (propionic acid [PPA]-induced autism model), and three (prenatal SSRI-exposed newborn rats whose mothers were exposed to 5 mg/kg of fluoxetine over gestation days 10–20). SSRI (fluoxetine) induced significant neurochemical abnormalities in the rat brain by increasing lipid peroxide (MDA), Interferon-gamma (IFN-γ), and caspase-3 levels and by depleting Glutathione (GSH), Glutathione S-transferases (GST), Catalase, potassium (K+), and Creatine kinase (CK) levels, similarly to what has been discovered in the PPA model of autism when compared with control. Prenatal fluoxetine exposure plays a significant role in asset brain damage in newborns; further investigation of fluoxetine as an autism risk factor is thus warranted. |
| first_indexed | 2024-03-11T08:26:01Z |
| format | Article |
| id | doaj.art-33c794e6e0874cd892994395f9a4f37a |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T08:26:01Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-33c794e6e0874cd892994395f9a4f37a2023-11-16T22:05:47ZengMDPI AGMetabolites2218-19892023-02-0113231010.3390/metabo13020310Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the BrainRamesa Shafi Bhat0Mona Alonazi1Sooad Al-Daihan2Afaf El-Ansary3Biochemistry Department, College of Science, King Saud University, Riyadh 11495, Saudi ArabiaBiochemistry Department, College of Science, King Saud University, Riyadh 11495, Saudi ArabiaBiochemistry Department, College of Science, King Saud University, Riyadh 11495, Saudi ArabiaCentral Research Laboratory, Female Campus, King Saud University, Riyadh 11495, Saudi ArabiaThe mechanisms underlying selective serotonin reuptake inhibitor (SSRI) use during pregnancy as a major autism risk factor are unclear. Here, brain neurochemical changes following fluoxetine exposure and in an autism model were compared to determine the effects on autism risk. The study was performed on neonatal male western albino rats which were divided into Groups one (control), two (propionic acid [PPA]-induced autism model), and three (prenatal SSRI-exposed newborn rats whose mothers were exposed to 5 mg/kg of fluoxetine over gestation days 10–20). SSRI (fluoxetine) induced significant neurochemical abnormalities in the rat brain by increasing lipid peroxide (MDA), Interferon-gamma (IFN-γ), and caspase-3 levels and by depleting Glutathione (GSH), Glutathione S-transferases (GST), Catalase, potassium (K+), and Creatine kinase (CK) levels, similarly to what has been discovered in the PPA model of autism when compared with control. Prenatal fluoxetine exposure plays a significant role in asset brain damage in newborns; further investigation of fluoxetine as an autism risk factor is thus warranted.https://www.mdpi.com/2218-1989/13/2/310SSRIautismoxidative stressneurotransmittersfluoxetine |
| spellingShingle | Ramesa Shafi Bhat Mona Alonazi Sooad Al-Daihan Afaf El-Ansary Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain Metabolites SSRI autism oxidative stress neurotransmitters fluoxetine |
| title | Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain |
| title_full | Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain |
| title_fullStr | Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain |
| title_full_unstemmed | Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain |
| title_short | Prenatal SSRI Exposure Increases the Risk of Autism in Rodents via Aggravated Oxidative Stress and Neurochemical Changes in the Brain |
| title_sort | prenatal ssri exposure increases the risk of autism in rodents via aggravated oxidative stress and neurochemical changes in the brain |
| topic | SSRI autism oxidative stress neurotransmitters fluoxetine |
| url | https://www.mdpi.com/2218-1989/13/2/310 |
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