Assessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy
Abstract Background To compare Gd-ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and 99mTc-labelled mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests after unilateral radioembolisation (RE) in patients with pri...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | European Radiology Experimental |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41747-023-00409-x |
| _version_ | 1797275907261464576 |
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| author | Matthias P. Fabritius Benjamin Garlipp Osman Öcal Daniel Puhr-Westerheide Holger Amthauer Thomas Geyer Adrien Holzgreve Jens Ricke Dennis Kupitz Oliver S. Grosser Jazan Omari Maciej Pech Max Seidensticker Freba Grawe Ricarda Seidensticker |
| author_facet | Matthias P. Fabritius Benjamin Garlipp Osman Öcal Daniel Puhr-Westerheide Holger Amthauer Thomas Geyer Adrien Holzgreve Jens Ricke Dennis Kupitz Oliver S. Grosser Jazan Omari Maciej Pech Max Seidensticker Freba Grawe Ricarda Seidensticker |
| author_sort | Matthias P. Fabritius |
| collection | DOAJ |
| description | Abstract Background To compare Gd-ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and 99mTc-labelled mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests after unilateral radioembolisation (RE) in patients with primary or secondary liver malignancies. Methods Twenty-three patients with primary or secondary liver malignancies who underwent Gd-EOB-DTPA-enhanced MRI within a prospective study (REVoluTion) were evaluated. REVoluTion was a prospective open-label, non-randomised, therapy-optimising study of patients undergoing right-sided or sequential RE for contralateral liver hypertrophy at a single centre in Germany. MRI and hepatobiliary scintigraphy were performed before RE (baseline) and 6 weeks after (follow-up). This exploratory subanalysis compared liver enhancement on hepatobiliary phase MRI normalised to the spleen (liver-to-spleen ratio (LSR)) and the muscle (liver-to-muscle ratio (LMR)) with mebrofenin uptake on HBS for the total liver (TL) and separately for the right (RLL) and left liver lobe (LLL). Results Mebrofenin uptake at baseline and follow-up each correlated significantly with LSR and LMR on MRI for TL (≤ 0.013) and RLL (≤ 0.049). Regarding the LLL, mebrofenin uptake correlated significantly with LMR (baseline, p = 0.013; follow-up, p = 0.004), whereas with LSR, a borderline significant correlation was only seen at follow-up (p = 0.051; p = 0.046). Conclusion LSRs and LMR correlate with mebrofenin uptake in HBS. This study indicates that Gd-EOB-DTPA-enhanced MRI and 99mTc-labelled mebrofenin HBS may equally be used to assess an increase in contralateral liver lobe function after right-sided RE. Relevance statement MRI may be a convenient and reliable method for assessing the future liver remnant facilitating treatment planning and monitoring of patients after RE-induced hypertrophy induction. Key points • Both MRI and HBS can assess liver function after RE. • Liver enhancement on MRI correlates with mebrofenin uptake on HBS. • MRI might be a convenient alternative for estimating future liver remnants after hypertrophy induction. Graphical Abstract |
| first_indexed | 2024-03-07T15:20:45Z |
| format | Article |
| id | doaj.art-33c82862ee194efba473284e416b417c |
| institution | Directory Open Access Journal |
| issn | 2509-9280 |
| language | English |
| last_indexed | 2024-03-07T15:20:45Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Radiology Experimental |
| spelling | doaj.art-33c82862ee194efba473284e416b417c2024-03-05T17:38:10ZengSpringerOpenEuropean Radiology Experimental2509-92802024-01-018111010.1186/s41747-023-00409-xAssessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphyMatthias P. Fabritius0Benjamin Garlipp1Osman Öcal2Daniel Puhr-Westerheide3Holger Amthauer4Thomas Geyer5Adrien Holzgreve6Jens Ricke7Dennis Kupitz8Oliver S. Grosser9Jazan Omari10Maciej Pech11Max Seidensticker12Freba Grawe13Ricarda Seidensticker14Department of Radiology, LMU University Hospital, LMU MunichGeneral Surgery, Otto Von Guericke UniversityDepartment of Radiology, LMU University Hospital, LMU MunichDepartment of Radiology, LMU University Hospital, LMU MunichDepartment of Nuclear Medicine, Charité-Universitätsmedizin BerlinDepartment of Radiology, LMU University Hospital, LMU MunichDepartment of Nuclear Medicine, LMU University Hospital, LMU MunichDepartment of Radiology, LMU University Hospital, LMU MunichDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-Von-Guericke UniversityDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-Von-Guericke UniversityDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-Von-Guericke UniversityDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-Von-Guericke UniversityDepartment of Radiology, LMU University Hospital, LMU MunichDepartment of Radiology, LMU University Hospital, LMU MunichDepartment of Radiology, LMU University Hospital, LMU MunichAbstract Background To compare Gd-ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and 99mTc-labelled mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests after unilateral radioembolisation (RE) in patients with primary or secondary liver malignancies. Methods Twenty-three patients with primary or secondary liver malignancies who underwent Gd-EOB-DTPA-enhanced MRI within a prospective study (REVoluTion) were evaluated. REVoluTion was a prospective open-label, non-randomised, therapy-optimising study of patients undergoing right-sided or sequential RE for contralateral liver hypertrophy at a single centre in Germany. MRI and hepatobiliary scintigraphy were performed before RE (baseline) and 6 weeks after (follow-up). This exploratory subanalysis compared liver enhancement on hepatobiliary phase MRI normalised to the spleen (liver-to-spleen ratio (LSR)) and the muscle (liver-to-muscle ratio (LMR)) with mebrofenin uptake on HBS for the total liver (TL) and separately for the right (RLL) and left liver lobe (LLL). Results Mebrofenin uptake at baseline and follow-up each correlated significantly with LSR and LMR on MRI for TL (≤ 0.013) and RLL (≤ 0.049). Regarding the LLL, mebrofenin uptake correlated significantly with LMR (baseline, p = 0.013; follow-up, p = 0.004), whereas with LSR, a borderline significant correlation was only seen at follow-up (p = 0.051; p = 0.046). Conclusion LSRs and LMR correlate with mebrofenin uptake in HBS. This study indicates that Gd-EOB-DTPA-enhanced MRI and 99mTc-labelled mebrofenin HBS may equally be used to assess an increase in contralateral liver lobe function after right-sided RE. Relevance statement MRI may be a convenient and reliable method for assessing the future liver remnant facilitating treatment planning and monitoring of patients after RE-induced hypertrophy induction. Key points • Both MRI and HBS can assess liver function after RE. • Liver enhancement on MRI correlates with mebrofenin uptake on HBS. • MRI might be a convenient alternative for estimating future liver remnants after hypertrophy induction. Graphical Abstracthttps://doi.org/10.1186/s41747-023-00409-xGadolinium ethoxybenzyl DTPALiverMagnetic resonance imagingTechnetium Tc 99 m mebrofeninRadioembolisation |
| spellingShingle | Matthias P. Fabritius Benjamin Garlipp Osman Öcal Daniel Puhr-Westerheide Holger Amthauer Thomas Geyer Adrien Holzgreve Jens Ricke Dennis Kupitz Oliver S. Grosser Jazan Omari Maciej Pech Max Seidensticker Freba Grawe Ricarda Seidensticker Assessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy European Radiology Experimental Gadolinium ethoxybenzyl DTPA Liver Magnetic resonance imaging Technetium Tc 99 m mebrofenin Radioembolisation |
| title | Assessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy |
| title_full | Assessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy |
| title_fullStr | Assessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy |
| title_full_unstemmed | Assessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy |
| title_short | Assessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy |
| title_sort | assessing regional hepatic function changes after hypertrophy induction by radioembolisation comparison of gadoxetic acid enhanced mri and 99mtc mebrofenin hepatobiliary scintigraphy |
| topic | Gadolinium ethoxybenzyl DTPA Liver Magnetic resonance imaging Technetium Tc 99 m mebrofenin Radioembolisation |
| url | https://doi.org/10.1186/s41747-023-00409-x |
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