Relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rate
Background: The association between cystatin C (CysC) and atherosclerosis has been shown in numerous studies in hypertensive patients and in various patient groups with high cardiovascular risk. The study examining the association between renal volume and atherosclerosis is very limited. This study...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-05-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2021.1890765 |
| _version_ | 1797681283301638144 |
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| author | Emrah Selvi Aysun Aybal Kutlugun Nuray Gulden Tangal Koza Murat Tolga Akkan Esin Beyan Selma Ramadan Uysal |
| author_facet | Emrah Selvi Aysun Aybal Kutlugun Nuray Gulden Tangal Koza Murat Tolga Akkan Esin Beyan Selma Ramadan Uysal |
| author_sort | Emrah Selvi |
| collection | DOAJ |
| description | Background: The association between cystatin C (CysC) and atherosclerosis has been shown in numerous studies in hypertensive patients and in various patient groups with high cardiovascular risk. The study examining the association between renal volume and atherosclerosis is very limited. This study aimed to investigate whether there is an association between the presence of atherosclerosis with CysC and renal volume in hypertensive patients. Methods: 133 hypertensive patients and 80 healthy volunteers were evaluated. CysC level was studied in the blood sample taken from all participants. Carotid intima media thickness (CIMT) and renal volume were measured with ultrasound always by the same radiologist. Laboratory findings, CysC, CIMT, and renal volume measurements of the groups were compared statistically. Results: There was no significant difference in mean renal volume values between hypertension and control groups. There was no significant correlation between renal volume with albuminuria and proteinuria. CIMT was significantly higher in hypertension group than in control group (p = .003). There was a significant correlation between renal volume and CIMT, which is an indicator of subclinical atherosclerosis (r = 0.213, p = .001). Renal volume was found to be an independent predictor of CIMT when corrected with variables such as age, BMI, serum LDL-cholesterol level, creatinine, CysC, and albumin-to-creatinine ratio. Conclusion: Ultrasonographic renal volume measurement, which is easy to perform and does not take a long time, can be a useful method for predicting the presence of atherosclerosis in hypertensive patients with GFR >60 ml/min. |
| first_indexed | 2024-03-11T23:42:43Z |
| format | Article |
| id | doaj.art-33ca87ac13f04226ae8345859e47c909 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:42:43Z |
| publishDate | 2021-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-33ca87ac13f04226ae8345859e47c9092023-09-19T15:19:29ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062021-05-0143437337710.1080/10641963.2021.18907651890765Relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rateEmrah Selvi0Aysun Aybal Kutlugun1Nuray Gulden Tangal2Koza Murat3Tolga Akkan4Esin Beyan5Selma Ramadan Uysal6Health Science University, Keçioren Training and Research HospitalHealth Science University, Keçioren Training and Research HospitalHealth Science University, Keçioren Training and Research HospitalHealth Science University, Keçioren Training and Research HospitalHealth Science University, Keçioren Training and Research HospitalHealth Science University, Keçioren Training and Research HospitalHealth Science University, Keçioren Training and Research HospitalBackground: The association between cystatin C (CysC) and atherosclerosis has been shown in numerous studies in hypertensive patients and in various patient groups with high cardiovascular risk. The study examining the association between renal volume and atherosclerosis is very limited. This study aimed to investigate whether there is an association between the presence of atherosclerosis with CysC and renal volume in hypertensive patients. Methods: 133 hypertensive patients and 80 healthy volunteers were evaluated. CysC level was studied in the blood sample taken from all participants. Carotid intima media thickness (CIMT) and renal volume were measured with ultrasound always by the same radiologist. Laboratory findings, CysC, CIMT, and renal volume measurements of the groups were compared statistically. Results: There was no significant difference in mean renal volume values between hypertension and control groups. There was no significant correlation between renal volume with albuminuria and proteinuria. CIMT was significantly higher in hypertension group than in control group (p = .003). There was a significant correlation between renal volume and CIMT, which is an indicator of subclinical atherosclerosis (r = 0.213, p = .001). Renal volume was found to be an independent predictor of CIMT when corrected with variables such as age, BMI, serum LDL-cholesterol level, creatinine, CysC, and albumin-to-creatinine ratio. Conclusion: Ultrasonographic renal volume measurement, which is easy to perform and does not take a long time, can be a useful method for predicting the presence of atherosclerosis in hypertensive patients with GFR >60 ml/min.http://dx.doi.org/10.1080/10641963.2021.1890765cystatin chypertensionrenal volumeatherosclerosis |
| spellingShingle | Emrah Selvi Aysun Aybal Kutlugun Nuray Gulden Tangal Koza Murat Tolga Akkan Esin Beyan Selma Ramadan Uysal Relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rate Clinical and Experimental Hypertension cystatin c hypertension renal volume atherosclerosis |
| title | Relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rate |
| title_full | Relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rate |
| title_fullStr | Relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rate |
| title_full_unstemmed | Relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rate |
| title_short | Relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rate |
| title_sort | relationship between renal volume and atherosclerosis in nondiabetic hypertensive patients with normal glomerular filtration rate |
| topic | cystatin c hypertension renal volume atherosclerosis |
| url | http://dx.doi.org/10.1080/10641963.2021.1890765 |
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