Significance of thyroid dysfunction in the patients with primary membranous nephropathy
Abstract Background Thyroid dysfunction is common in patients with nephrotic syndrome, especially patients with primary membranous nephropathy (pMN). In view of both MN and thyroid dysfunction are associated with autoimmunity, the current study aimed to elucidate the significance of thyroid dysfunct...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-022-03023-y |
| _version_ | 1811301862664568832 |
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| author | Qiu-hua Gu Xin Cao Xiao-ming Mao Jun-ya Jia Tie-kun Yan |
| author_facet | Qiu-hua Gu Xin Cao Xiao-ming Mao Jun-ya Jia Tie-kun Yan |
| author_sort | Qiu-hua Gu |
| collection | DOAJ |
| description | Abstract Background Thyroid dysfunction is common in patients with nephrotic syndrome, especially patients with primary membranous nephropathy (pMN). In view of both MN and thyroid dysfunction are associated with autoimmunity, the current study aimed to elucidate the significance of thyroid dysfunction in patients with pMN. Methods Four hundred and twenty patients with biopsy-proven pMN from 2018–2021 were retrospectively enrolled. Clinical and pathological parameters, and treatment response of patients with and without thyroid dysfunction were analyzed. Results Ninety-one (21.7%) patients with pMN suffered from thyroid dysfunction, among which subclinical hypothyroidism (52.7%) was the main disorder. Compared to patients with normal thyroid function, patients with thyroid dysfunction presented with a higher level of proteinuria, a lower level of serum albumin, a higher level of serum creatinine and more severe tubulointerstitial injury at the time of biopsy. But the positive rate and level of circulating anti-phospholipase A2 receptor (PLA2R) antibody were comparable between these two groups. Though following the similar treatment, the percentage of no response to treatment were significantly higher in the patients with thyroid dysfunction (38.6 vs. 20.0%, P = 0.003). Similar to the urinary protein and the positivity of anti-PLA2R antibody, multivariate COX analysis showed thyroid dysfunction was also identified as an independent risk factor for the failure to remission (HR = 1.91, 95%CI, 1.07–3.40, P = 0.029). Conclusion In conclusion, thyroid dysfunction is common in the patients with pMN and might predict a severe clinical manifestation and a poor clinical outcome, which indicated that the thyroid dysfunction might be involved in the disease progression of pMN. |
| first_indexed | 2024-04-13T07:17:46Z |
| format | Article |
| id | doaj.art-33cd0581daad42ba99ed0c0052503057 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-13T07:17:46Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-33cd0581daad42ba99ed0c00525030572022-12-22T02:56:43ZengBMCBMC Nephrology1471-23692022-12-0123111010.1186/s12882-022-03023-ySignificance of thyroid dysfunction in the patients with primary membranous nephropathyQiu-hua Gu0Xin Cao1Xiao-ming Mao2Jun-ya Jia3Tie-kun Yan4Department of Nephrology, Tianjin Medical University General HospitalDepartment of Nephrology, Tianjin Medical University General Hospital Airport HospitalDepartment of Nephrology, Tianjin Medical University General HospitalDepartment of Nephrology, Tianjin Medical University General HospitalDepartment of Nephrology, Tianjin Medical University General HospitalAbstract Background Thyroid dysfunction is common in patients with nephrotic syndrome, especially patients with primary membranous nephropathy (pMN). In view of both MN and thyroid dysfunction are associated with autoimmunity, the current study aimed to elucidate the significance of thyroid dysfunction in patients with pMN. Methods Four hundred and twenty patients with biopsy-proven pMN from 2018–2021 were retrospectively enrolled. Clinical and pathological parameters, and treatment response of patients with and without thyroid dysfunction were analyzed. Results Ninety-one (21.7%) patients with pMN suffered from thyroid dysfunction, among which subclinical hypothyroidism (52.7%) was the main disorder. Compared to patients with normal thyroid function, patients with thyroid dysfunction presented with a higher level of proteinuria, a lower level of serum albumin, a higher level of serum creatinine and more severe tubulointerstitial injury at the time of biopsy. But the positive rate and level of circulating anti-phospholipase A2 receptor (PLA2R) antibody were comparable between these two groups. Though following the similar treatment, the percentage of no response to treatment were significantly higher in the patients with thyroid dysfunction (38.6 vs. 20.0%, P = 0.003). Similar to the urinary protein and the positivity of anti-PLA2R antibody, multivariate COX analysis showed thyroid dysfunction was also identified as an independent risk factor for the failure to remission (HR = 1.91, 95%CI, 1.07–3.40, P = 0.029). Conclusion In conclusion, thyroid dysfunction is common in the patients with pMN and might predict a severe clinical manifestation and a poor clinical outcome, which indicated that the thyroid dysfunction might be involved in the disease progression of pMN.https://doi.org/10.1186/s12882-022-03023-yMembranous nephropathyThyroid dysfunctionAnti-PLA2R antibody |
| spellingShingle | Qiu-hua Gu Xin Cao Xiao-ming Mao Jun-ya Jia Tie-kun Yan Significance of thyroid dysfunction in the patients with primary membranous nephropathy BMC Nephrology Membranous nephropathy Thyroid dysfunction Anti-PLA2R antibody |
| title | Significance of thyroid dysfunction in the patients with primary membranous nephropathy |
| title_full | Significance of thyroid dysfunction in the patients with primary membranous nephropathy |
| title_fullStr | Significance of thyroid dysfunction in the patients with primary membranous nephropathy |
| title_full_unstemmed | Significance of thyroid dysfunction in the patients with primary membranous nephropathy |
| title_short | Significance of thyroid dysfunction in the patients with primary membranous nephropathy |
| title_sort | significance of thyroid dysfunction in the patients with primary membranous nephropathy |
| topic | Membranous nephropathy Thyroid dysfunction Anti-PLA2R antibody |
| url | https://doi.org/10.1186/s12882-022-03023-y |
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