Inflammatory pathophysiological mechanisms implicated in postpartum depression
Postpartum Depression (PPD) is a serious psychiatric disorder of women within the first year after delivery. It grievously damages women’s physical and mental health. Inflammatory reaction theory is well-established in depression, and also has been reported associated with PPD. This review summarize...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.955672/full |
| _version_ | 1797991402650468352 |
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| author | Jialei Zhu Jing Jin Jing Tang |
| author_facet | Jialei Zhu Jing Jin Jing Tang |
| author_sort | Jialei Zhu |
| collection | DOAJ |
| description | Postpartum Depression (PPD) is a serious psychiatric disorder of women within the first year after delivery. It grievously damages women’s physical and mental health. Inflammatory reaction theory is well-established in depression, and also has been reported associated with PPD. This review summarized the inflammatory pathophysiological mechanisms implicated in PPD, including decreased T cell activation, increased proinflammatory cytokines secretion, active kynurenine pathway, and initiated NLRP3 inflammasome. Clinical and preclinical research are both gathered. Potential therapeutical alternatives targeting the inflammatory mechanisms of PPD were introduced. In addition, this review briefly discussed the differences of inflammatory mechanisms between PPD and depression. The research of inflammation in PPD is limited and seems just embarking, which indicates the direction we can further study. As a variety of risky factors contribute to PPD collectively, therapy for women with PPD should be comprehensive, and clinical heterogeneity should be taken into consideration. As PPD has a predictability, early clinical screening and interventions are also needed. This review aims to help readers better understand the inflammatory pathological mechanisms in PPD, so as to identify biomarkers and potential therapeutic targets in the future. |
| first_indexed | 2024-04-11T08:51:41Z |
| format | Article |
| id | doaj.art-33cd1d58b0794e4ca4b883319d3f47da |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T08:51:41Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-33cd1d58b0794e4ca4b883319d3f47da2022-12-22T04:33:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.955672955672Inflammatory pathophysiological mechanisms implicated in postpartum depressionJialei ZhuJing JinJing TangPostpartum Depression (PPD) is a serious psychiatric disorder of women within the first year after delivery. It grievously damages women’s physical and mental health. Inflammatory reaction theory is well-established in depression, and also has been reported associated with PPD. This review summarized the inflammatory pathophysiological mechanisms implicated in PPD, including decreased T cell activation, increased proinflammatory cytokines secretion, active kynurenine pathway, and initiated NLRP3 inflammasome. Clinical and preclinical research are both gathered. Potential therapeutical alternatives targeting the inflammatory mechanisms of PPD were introduced. In addition, this review briefly discussed the differences of inflammatory mechanisms between PPD and depression. The research of inflammation in PPD is limited and seems just embarking, which indicates the direction we can further study. As a variety of risky factors contribute to PPD collectively, therapy for women with PPD should be comprehensive, and clinical heterogeneity should be taken into consideration. As PPD has a predictability, early clinical screening and interventions are also needed. This review aims to help readers better understand the inflammatory pathological mechanisms in PPD, so as to identify biomarkers and potential therapeutic targets in the future.https://www.frontiersin.org/articles/10.3389/fphar.2022.955672/fullpostpartum depressioninflammationT cellcytokinekynurenineinflammasome |
| spellingShingle | Jialei Zhu Jing Jin Jing Tang Inflammatory pathophysiological mechanisms implicated in postpartum depression Frontiers in Pharmacology postpartum depression inflammation T cell cytokine kynurenine inflammasome |
| title | Inflammatory pathophysiological mechanisms implicated in postpartum depression |
| title_full | Inflammatory pathophysiological mechanisms implicated in postpartum depression |
| title_fullStr | Inflammatory pathophysiological mechanisms implicated in postpartum depression |
| title_full_unstemmed | Inflammatory pathophysiological mechanisms implicated in postpartum depression |
| title_short | Inflammatory pathophysiological mechanisms implicated in postpartum depression |
| title_sort | inflammatory pathophysiological mechanisms implicated in postpartum depression |
| topic | postpartum depression inflammation T cell cytokine kynurenine inflammasome |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.955672/full |
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