Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation[S]

Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation[S]

Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in inflammation. Their generation by cellular cyclooxygenases (COXs) is currently unknown. To determine whether platelets generate prostaglandin (PG)-containing oxPLs, then characterize their structures...

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Bibliographic Details
Main Authors: Maceler Aldrovandi, Victoria J. Hammond, Helen Podmore, Martin Hornshaw, Stephen R. Clark, Lawrence J. Marnett, David A. Slatter, Robert C. Murphy, Peter W. Collins, Valerie B. O'Donnell
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Journal of Lipid Research
Subjects:
Oxidized phospholipids
atherosclerosis
PGE2/D2-PEs
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350604

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