Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria

Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria

Abstract Malaria has provided a major selective pressure and has modulated the genetic diversity of the human genome. The variants of the Duffy Antigen/Receptor for Chemokines (DARC) gene have probably been selected by malaria parasites, particularly the FY*O allele, which is fixed in sub-Saharan Af...

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Bibliographic Details
Main Authors: Flora Satiko Kano, Aracele Maria de Souza, Leticia de Menezes Torres, Marcelo Azevedo Costa, Flávia Alessandra Souza-Silva, Bruno Antônio Marinho Sanchez, Cor Jesus Fernandes Fontes, Irene Silva Soares, Cristiana Ferreira Alves de Brito, Luzia Helena Carvalho, Tais Nobrega Sousa
Format: Article
Language:English
Published: Nature Portfolio 2018-09-01
Series:Scientific Reports
Subjects:
Duffy Antigen Receptor For Chemokines (DARC)
Vivax Malaria
Genomic Ancestry
Clinical Malaria
Ancestry Informative Markers (AIMs)
Online Access:https://doi.org/10.1038/s41598-018-32254-z

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