Nutraceuticals and Enteric Glial Cells
Until recently, glia were considered to be a structural support for neurons, however further investigations showed that glial cells are equally as important as neurons. Among many different types of glia, enteric glial cells (EGCs) found in the gastrointestinal tract, have been significantly underes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/12/3762 |
| _version_ | 1797529409813479424 |
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| author | Laura López-Gómez Agata Szymaszkiewicz Marta Zielińska Raquel Abalo |
| author_facet | Laura López-Gómez Agata Szymaszkiewicz Marta Zielińska Raquel Abalo |
| author_sort | Laura López-Gómez |
| collection | DOAJ |
| description | Until recently, glia were considered to be a structural support for neurons, however further investigations showed that glial cells are equally as important as neurons. Among many different types of glia, enteric glial cells (EGCs) found in the gastrointestinal tract, have been significantly underestimated, but proved to play an essential role in neuroprotection, immune system modulation and many other functions. They are also said to be remarkably altered in different physiopathological conditions. A nutraceutical is defined as any food substance or part of a food that provides medical or health benefits, including prevention and treatment of the disease. Following the description of these interesting peripheral glial cells and highlighting their role in physiological and pathological changes, this article reviews all the studies on the effects of nutraceuticals as modulators of their functions. Currently there are only a few studies available concerning the effects of nutraceuticals on EGCs. Most of them evaluated molecules with antioxidant properties in systemic conditions, whereas only a few studies have been performed using models of gastrointestinal disorders. Despite the scarcity of studies on the topic, all agree that nutraceuticals have the potential to be an interesting alternative in the prevention and/or treatment of enteric gliopathies (of systemic or local etiology) and their associated gastrointestinal conditions. |
| first_indexed | 2024-03-10T10:13:28Z |
| format | Article |
| id | doaj.art-33d1f5d3947b46a1be5b95cc3fccd1f9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:13:28Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-33d1f5d3947b46a1be5b95cc3fccd1f92023-11-22T00:59:03ZengMDPI AGMolecules1420-30492021-06-012612376210.3390/molecules26123762Nutraceuticals and Enteric Glial CellsLaura López-Gómez0Agata Szymaszkiewicz1Marta Zielińska2Raquel Abalo3High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Department of Basic Health Sciences, University Rey Juan Carlos, 28933 Alcorcón, SpainDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, 90-419 Lodz, PolandHigh Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Department of Basic Health Sciences, University Rey Juan Carlos, 28933 Alcorcón, SpainUntil recently, glia were considered to be a structural support for neurons, however further investigations showed that glial cells are equally as important as neurons. Among many different types of glia, enteric glial cells (EGCs) found in the gastrointestinal tract, have been significantly underestimated, but proved to play an essential role in neuroprotection, immune system modulation and many other functions. They are also said to be remarkably altered in different physiopathological conditions. A nutraceutical is defined as any food substance or part of a food that provides medical or health benefits, including prevention and treatment of the disease. Following the description of these interesting peripheral glial cells and highlighting their role in physiological and pathological changes, this article reviews all the studies on the effects of nutraceuticals as modulators of their functions. Currently there are only a few studies available concerning the effects of nutraceuticals on EGCs. Most of them evaluated molecules with antioxidant properties in systemic conditions, whereas only a few studies have been performed using models of gastrointestinal disorders. Despite the scarcity of studies on the topic, all agree that nutraceuticals have the potential to be an interesting alternative in the prevention and/or treatment of enteric gliopathies (of systemic or local etiology) and their associated gastrointestinal conditions.https://www.mdpi.com/1420-3049/26/12/3762coffeeenteric glial cellsgliainflammatory bowel diseaseirritable bowel syndromeneuropathic pain |
| spellingShingle | Laura López-Gómez Agata Szymaszkiewicz Marta Zielińska Raquel Abalo Nutraceuticals and Enteric Glial Cells Molecules coffee enteric glial cells glia inflammatory bowel disease irritable bowel syndrome neuropathic pain |
| title | Nutraceuticals and Enteric Glial Cells |
| title_full | Nutraceuticals and Enteric Glial Cells |
| title_fullStr | Nutraceuticals and Enteric Glial Cells |
| title_full_unstemmed | Nutraceuticals and Enteric Glial Cells |
| title_short | Nutraceuticals and Enteric Glial Cells |
| title_sort | nutraceuticals and enteric glial cells |
| topic | coffee enteric glial cells glia inflammatory bowel disease irritable bowel syndrome neuropathic pain |
| url | https://www.mdpi.com/1420-3049/26/12/3762 |
| work_keys_str_mv | AT lauralopezgomez nutraceuticalsandentericglialcells AT agataszymaszkiewicz nutraceuticalsandentericglialcells AT martazielinska nutraceuticalsandentericglialcells AT raquelabalo nutraceuticalsandentericglialcells |