The MELD-XI score predicts 3-year mortality in patients with chronic heart failure
ObjectivesThe relationship between the MELD-XI score, a modified version of the MELD score, and the long-term prognosis of hospitalized patients with chronic heart failure is unclear. The aim of this study was to determine the long-term prognostic relationship of MELD-XI score in patients with chron...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.985503/full |
| _version_ | 1811217065223127040 |
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| author | Zebin Lin Xia Liu Xia Liu Xia Liu Li Xiao Yin Li Chenlu Qi Siqi Song Yiping Zhao Lili Zou |
| author_facet | Zebin Lin Xia Liu Xia Liu Xia Liu Li Xiao Yin Li Chenlu Qi Siqi Song Yiping Zhao Lili Zou |
| author_sort | Zebin Lin |
| collection | DOAJ |
| description | ObjectivesThe relationship between the MELD-XI score, a modified version of the MELD score, and the long-term prognosis of hospitalized patients with chronic heart failure is unclear. The aim of this study was to determine the long-term prognostic relationship of MELD-XI score in patients with chronic heart failure.MethodsThis is a retrospective cohort study of patients with chronic heart failure who were initially hospitalized in the Second Affiliated Hospital of Chongqing Medical University from February 2017 to December 2017. The primary clinical outcome was all-cause mortality within 3 years. Cox regression and lasso regression were used to screen variables and build a prognostic model. Combined with the MELD-XI score, the final model was adjusted, and the predictive ability of the model was evaluated. Survival curves were estimated using the Kaplan–Meier method and compared by the log rank test.ResultsA total of 400 patients with chronic heart failure were included (median age 76 years, 51.5% female). During the 3-year follow-up period, there were 97 all-cause deaths, including 63 cardiac deaths. Six characteristic variables (NT-proBNP, BUN, RDW CV, Na+ and prealbumin) were selected by univariate Cox regression and lasso regression. Survival analysis results showed that elevated MELD-XI score at baseline predicted the risk of all-cause mortality at 3 years in patients (HR 3.19, 95% CI 2.11–4.82, P < 0.001; HRadjusted 1.79, 95% CI 1.09–2.92, P = 0.020). Subgroup analysis showed that MELD-XI score still had prognostic value in the subgroup without chronic kidney disease (HR 3.30 95%CI 2.01–5.42 P < 0.001; HRadjusted 1.88 95%CI 1.06–3.35 P = 0.032, P for interaction = 0.038).ConclusionsThis study proved that the MELD-XI score at admission was related to the poor prognosis of hospitalized patients with chronic heart failure within 3 years. |
| first_indexed | 2024-04-12T06:47:56Z |
| format | Article |
| id | doaj.art-33d22d2227fb4b4399f2ba664a40f81c |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T06:47:56Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-33d22d2227fb4b4399f2ba664a40f81c2022-12-22T03:43:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-08-01910.3389/fcvm.2022.985503985503The MELD-XI score predicts 3-year mortality in patients with chronic heart failureZebin Lin0Xia Liu1Xia Liu2Xia Liu3Li Xiao4Yin Li5Chenlu Qi6Siqi Song7Yiping Zhao8Lili Zou9Department of Geriatrics, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, ChinaDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Bengbu Medical College, Bengbu, ChinaAnhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Bengbu, ChinaClinical Research Center for Respiratory Disease (tumor) in Anhui Province, Bengbu, ChinaDepartment of General Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of General Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of General Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Cardiology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaObjectivesThe relationship between the MELD-XI score, a modified version of the MELD score, and the long-term prognosis of hospitalized patients with chronic heart failure is unclear. The aim of this study was to determine the long-term prognostic relationship of MELD-XI score in patients with chronic heart failure.MethodsThis is a retrospective cohort study of patients with chronic heart failure who were initially hospitalized in the Second Affiliated Hospital of Chongqing Medical University from February 2017 to December 2017. The primary clinical outcome was all-cause mortality within 3 years. Cox regression and lasso regression were used to screen variables and build a prognostic model. Combined with the MELD-XI score, the final model was adjusted, and the predictive ability of the model was evaluated. Survival curves were estimated using the Kaplan–Meier method and compared by the log rank test.ResultsA total of 400 patients with chronic heart failure were included (median age 76 years, 51.5% female). During the 3-year follow-up period, there were 97 all-cause deaths, including 63 cardiac deaths. Six characteristic variables (NT-proBNP, BUN, RDW CV, Na+ and prealbumin) were selected by univariate Cox regression and lasso regression. Survival analysis results showed that elevated MELD-XI score at baseline predicted the risk of all-cause mortality at 3 years in patients (HR 3.19, 95% CI 2.11–4.82, P < 0.001; HRadjusted 1.79, 95% CI 1.09–2.92, P = 0.020). Subgroup analysis showed that MELD-XI score still had prognostic value in the subgroup without chronic kidney disease (HR 3.30 95%CI 2.01–5.42 P < 0.001; HRadjusted 1.88 95%CI 1.06–3.35 P = 0.032, P for interaction = 0.038).ConclusionsThis study proved that the MELD-XI score at admission was related to the poor prognosis of hospitalized patients with chronic heart failure within 3 years.https://www.frontiersin.org/articles/10.3389/fcvm.2022.985503/fullMELD-XI scorechronic heart failureprediction modelcreatininebilirubin |
| spellingShingle | Zebin Lin Xia Liu Xia Liu Xia Liu Li Xiao Yin Li Chenlu Qi Siqi Song Yiping Zhao Lili Zou The MELD-XI score predicts 3-year mortality in patients with chronic heart failure Frontiers in Cardiovascular Medicine MELD-XI score chronic heart failure prediction model creatinine bilirubin |
| title | The MELD-XI score predicts 3-year mortality in patients with chronic heart failure |
| title_full | The MELD-XI score predicts 3-year mortality in patients with chronic heart failure |
| title_fullStr | The MELD-XI score predicts 3-year mortality in patients with chronic heart failure |
| title_full_unstemmed | The MELD-XI score predicts 3-year mortality in patients with chronic heart failure |
| title_short | The MELD-XI score predicts 3-year mortality in patients with chronic heart failure |
| title_sort | meld xi score predicts 3 year mortality in patients with chronic heart failure |
| topic | MELD-XI score chronic heart failure prediction model creatinine bilirubin |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.985503/full |
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