Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel Tubes
Hollow collagen gels are promising materials for drug/cell delivery systems to promote tissue regeneration because they may be able to function as carriers for these types of loads. Controlling the cavity size and swelling suppression is essential to expand the applications and improve the usability...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/6/458 |
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| author | Yu Ishibashi Ryota Haraguchi Shigehisa Aoki Yushi Oishi Takayuki Narita |
| author_facet | Yu Ishibashi Ryota Haraguchi Shigehisa Aoki Yushi Oishi Takayuki Narita |
| author_sort | Yu Ishibashi |
| collection | DOAJ |
| description | Hollow collagen gels are promising materials for drug/cell delivery systems to promote tissue regeneration because they may be able to function as carriers for these types of loads. Controlling the cavity size and swelling suppression is essential to expand the applications and improve the usability of such gel-like systems. We investigated the effects of UV-treated collagen solutions as a pre-gel aqueous mixture on the formation and properties of the hollow collagen gels in terms of their preparation range limits, morphology, and swelling ratio. The UV treatment thickened the pre-gel solutions, which allowed hollowing at lower collagen concentrations. This treatment also prevents the over-swelling of the hollow collagen rods in PBS buffer solutions. The UV-treated collagen solutions provided a large lumen space in the prepared collagen hollow fiber rods with a limited swelling ratio, allowing vascular endothelial cells and ectodermal cells to be cultured separately in the outer and inner lumen. |
| first_indexed | 2024-03-11T02:26:12Z |
| format | Article |
| id | doaj.art-33d4a6f1584f402c8ec03b67d49f89e6 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T02:26:12Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-33d4a6f1584f402c8ec03b67d49f89e62023-11-18T10:32:13ZengMDPI AGGels2310-28612023-06-019645810.3390/gels9060458Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel TubesYu Ishibashi0Ryota Haraguchi1Shigehisa Aoki2Yushi Oishi3Takayuki Narita4Department of Chemistry and Applied Chemistry, Saga University, Saga 840–8502, JapanDepartment of Chemistry and Applied Chemistry, Saga University, Saga 840–8502, JapanDepartment of Pathology and Microbiology, Saga University, Saga 849-8501, JapanDepartment of Chemistry and Applied Chemistry, Saga University, Saga 840–8502, JapanDepartment of Chemistry and Applied Chemistry, Saga University, Saga 840–8502, JapanHollow collagen gels are promising materials for drug/cell delivery systems to promote tissue regeneration because they may be able to function as carriers for these types of loads. Controlling the cavity size and swelling suppression is essential to expand the applications and improve the usability of such gel-like systems. We investigated the effects of UV-treated collagen solutions as a pre-gel aqueous mixture on the formation and properties of the hollow collagen gels in terms of their preparation range limits, morphology, and swelling ratio. The UV treatment thickened the pre-gel solutions, which allowed hollowing at lower collagen concentrations. This treatment also prevents the over-swelling of the hollow collagen rods in PBS buffer solutions. The UV-treated collagen solutions provided a large lumen space in the prepared collagen hollow fiber rods with a limited swelling ratio, allowing vascular endothelial cells and ectodermal cells to be cultured separately in the outer and inner lumen.https://www.mdpi.com/2310-2861/9/6/458collagenhollow structureultraviolet light modificationphoto-cross-linkingpre-gel solution |
| spellingShingle | Yu Ishibashi Ryota Haraguchi Shigehisa Aoki Yushi Oishi Takayuki Narita Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel Tubes Gels collagen hollow structure ultraviolet light modification photo-cross-linking pre-gel solution |
| title | Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel Tubes |
| title_full | Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel Tubes |
| title_fullStr | Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel Tubes |
| title_full_unstemmed | Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel Tubes |
| title_short | Effect of UV Irradiation of Pre-Gel Solutions on the Formation of Collagen Gel Tubes |
| title_sort | effect of uv irradiation of pre gel solutions on the formation of collagen gel tubes |
| topic | collagen hollow structure ultraviolet light modification photo-cross-linking pre-gel solution |
| url | https://www.mdpi.com/2310-2861/9/6/458 |
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