Functionally aberrant electrophysiological cortical connectivities in first episode medication-naive schizophrenics from three psychiatry centers
Functional dissociation between brain processes is widely hypothesized to account for aberrations of thought and emotions in schizophrenic patients. The typically small groups of analyzed schizophrenic patients yielded different neurophysiological findings, probably because small patient groups are...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00635/full |
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| author | Dietrich eLehmann‡ Pascal L Faber Roberto D Pascual-Marqui Patricia eMilz Werner M Herrmann‡ Martha eKoukkou Naomi eSaito Georg eWinterer Kieko eKochi |
| author_facet | Dietrich eLehmann‡ Pascal L Faber Roberto D Pascual-Marqui Patricia eMilz Werner M Herrmann‡ Martha eKoukkou Naomi eSaito Georg eWinterer Kieko eKochi |
| author_sort | Dietrich eLehmann‡ |
| collection | DOAJ |
| description | Functional dissociation between brain processes is widely hypothesized to account for aberrations of thought and emotions in schizophrenic patients. The typically small groups of analyzed schizophrenic patients yielded different neurophysiological findings, probably because small patient groups are likely to comprise different schizophrenia subtypes. We analyzed multichannel eyes-closed resting EEG from three small groups of acutely ill, first episode productive schizophrenic patients before start of medication (from three centers: Bern N=9; Osaka N=9; Berlin N=12) and their controls. Low resolution brain electromagnetic tomography (LORETA) was used to compute intracortical source model-based lagged functional connectivity not biased by volume conduction effects between 19 cortical regions of interest (ROIs). The connectivities were compared between controls and patients of each group. Conjunction analysis determined six aberrant cortical functional connectivities that were the same in the three patient groups. Four of these six concerned the facilitating EEG alpha 1 frequency activity; they were decreased in the patients. Another two of these six connectivities concerned the inhibiting EEG delta frequency activity; they were increased in the patients. The principal orientation of the six aberrant cortical functional connectivities was sagittal; five of them involved both hemispheres. In sum, activity in the posterior brain areas of preprocessing functions and the anterior brain areas of evaluation and behavior control functions were compromised by either decreased coupled activation or increased coupled inhibition, common across schizophrenia subtypes in the three patient groups. These results of the analyzed three independent groups of schizophrenics support the concept of functional dissociation. |
| first_indexed | 2024-12-10T06:24:16Z |
| format | Article |
| id | doaj.art-33d515f107524b84a805a9f09328f639 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-10T06:24:16Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-33d515f107524b84a805a9f09328f6392022-12-22T01:59:15ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612014-08-01810.3389/fnhum.2014.0063596803Functionally aberrant electrophysiological cortical connectivities in first episode medication-naive schizophrenics from three psychiatry centersDietrich eLehmann‡0Pascal L Faber1Roberto D Pascual-Marqui2Patricia eMilz3Werner M Herrmann‡4Martha eKoukkou5Naomi eSaito6Georg eWinterer7Kieko eKochi8The KEY Institute for Brain-Mind Research, University of ZurichThe KEY Institute for Brain-Mind Research, University of ZurichThe KEY Institute for Brain-Mind Research, University of ZurichThe KEY Institute for Brain-Mind Research, University of ZurichLaboratory of Clinical Psychophysiology, Dept. of Psychiatry, University Hospital Benjamin Franklin, Free University of Berlin, GermanyThe KEY Institute for Brain-Mind Research, University of ZurichSaito Mental Clinic, Osaka, JapanCharité – University Medicine Berlin, Experimental and Clinical Research Center, Campus Buch, Berlin, GermanyThe KEY Institute for Brain-Mind Research, University of ZurichFunctional dissociation between brain processes is widely hypothesized to account for aberrations of thought and emotions in schizophrenic patients. The typically small groups of analyzed schizophrenic patients yielded different neurophysiological findings, probably because small patient groups are likely to comprise different schizophrenia subtypes. We analyzed multichannel eyes-closed resting EEG from three small groups of acutely ill, first episode productive schizophrenic patients before start of medication (from three centers: Bern N=9; Osaka N=9; Berlin N=12) and their controls. Low resolution brain electromagnetic tomography (LORETA) was used to compute intracortical source model-based lagged functional connectivity not biased by volume conduction effects between 19 cortical regions of interest (ROIs). The connectivities were compared between controls and patients of each group. Conjunction analysis determined six aberrant cortical functional connectivities that were the same in the three patient groups. Four of these six concerned the facilitating EEG alpha 1 frequency activity; they were decreased in the patients. Another two of these six connectivities concerned the inhibiting EEG delta frequency activity; they were increased in the patients. The principal orientation of the six aberrant cortical functional connectivities was sagittal; five of them involved both hemispheres. In sum, activity in the posterior brain areas of preprocessing functions and the anterior brain areas of evaluation and behavior control functions were compromised by either decreased coupled activation or increased coupled inhibition, common across schizophrenia subtypes in the three patient groups. These results of the analyzed three independent groups of schizophrenics support the concept of functional dissociation.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00635/fullEEGfunctional connectivityLORETAfunctional dissociationschizophrenic subtypescortical source modeling |
| spellingShingle | Dietrich eLehmann‡ Pascal L Faber Roberto D Pascual-Marqui Patricia eMilz Werner M Herrmann‡ Martha eKoukkou Naomi eSaito Georg eWinterer Kieko eKochi Functionally aberrant electrophysiological cortical connectivities in first episode medication-naive schizophrenics from three psychiatry centers Frontiers in Human Neuroscience EEG functional connectivity LORETA functional dissociation schizophrenic subtypes cortical source modeling |
| title | Functionally aberrant electrophysiological cortical connectivities in first episode medication-naive schizophrenics from three psychiatry centers |
| title_full | Functionally aberrant electrophysiological cortical connectivities in first episode medication-naive schizophrenics from three psychiatry centers |
| title_fullStr | Functionally aberrant electrophysiological cortical connectivities in first episode medication-naive schizophrenics from three psychiatry centers |
| title_full_unstemmed | Functionally aberrant electrophysiological cortical connectivities in first episode medication-naive schizophrenics from three psychiatry centers |
| title_short | Functionally aberrant electrophysiological cortical connectivities in first episode medication-naive schizophrenics from three psychiatry centers |
| title_sort | functionally aberrant electrophysiological cortical connectivities in first episode medication naive schizophrenics from three psychiatry centers |
| topic | EEG functional connectivity LORETA functional dissociation schizophrenic subtypes cortical source modeling |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00635/full |
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