In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy

Raman spectroscopic imaging (RSI) can provide information on the chemical composition of a sample, but application to living organisms has lacked sufficient spatial resolution and signal strength. Here the authors apply confocal RSI to whole-mount zebrafish embryos to distinguish different infectiou...

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Bibliografski detalji
Glavni autori: Håkon Høgset, Conor C. Horgan, James P. K. Armstrong, Mads S. Bergholt, Vincenzo Torraca, Qu Chen, Timothy J. Keane, Laurence Bugeon, Margaret J. Dallman, Serge Mostowy, Molly M. Stevens
Format: Članak
Jezik:English
Izdano: Nature Portfolio 2020-12-01
Serija:Nature Communications
Online pristup:https://doi.org/10.1038/s41467-020-19827-1
Opis
Sažetak:Raman spectroscopic imaging (RSI) can provide information on the chemical composition of a sample, but application to living organisms has lacked sufficient spatial resolution and signal strength. Here the authors apply confocal RSI to whole-mount zebrafish embryos to distinguish different infectious bacteria and to living zebrafish embryos to monitor the wound healing process.
ISSN:2041-1723