Inflammatory-like status and acute stress response in horses after road transport
Abstract This study aimed to evaluate the change of white blood cell count, serum concentration of cortisol, C-reactive protein, albumin and globulin fractions in horse after road transport, and to assess the linkage among hypothalamic–pituitary–adrenal axis (HPA) and inflammatory reaction. From 10...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-37069-1 |
| _version_ | 1797801424809099264 |
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| author | Francesca Arfuso Maria Rizzo Claudia Giannetto Elisabetta Giudice Giuseppe Piccione Francesco Fazio Roberta Cirincione Giovanni Cassata Luca Cicero |
| author_facet | Francesca Arfuso Maria Rizzo Claudia Giannetto Elisabetta Giudice Giuseppe Piccione Francesco Fazio Roberta Cirincione Giovanni Cassata Luca Cicero |
| author_sort | Francesca Arfuso |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the change of white blood cell count, serum concentration of cortisol, C-reactive protein, albumin and globulin fractions in horse after road transport, and to assess the linkage among hypothalamic–pituitary–adrenal axis (HPA) and inflammatory reaction. From 10 horses blood samples were collected at rest, before road transport (218 km) (BT); after unloaded (AT), 30 and 60 min after unloaded (AT30 and AT60) in order to assess white blood cell count (WBC), serum cortisol, C-reactive protein (CRP), total proteins, albumin, α1-, α-2, β1-, β2- and γ-globulins. WBC, cortisol, CRP, α1-, α-2 and β2-globulins values increased after road transport than rest condition (p < 0.001). Albumin and A/G ratio showed lower values after road transport than rest (p < 0.001). Pearson’s test showed a negative correlation between cortisol and the values of WBC, CRP, α1-, α2-, β1-, β2- globulins, and a positive correlation between WBC and serum concentration of CRP, α1- and α2-, β1-, β2-globulins at AT and AT30. The results showed that road transport evokes an inflammatory like-status in horses. Moreover, the activation of HPA and the onset of acute phase reaction in response to road transport seem to be interconnected with effects on horse’s immune status. |
| first_indexed | 2024-03-13T04:50:16Z |
| format | Article |
| id | doaj.art-33d8a407cf0c4600a2f608fab5f51648 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T04:50:16Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-33d8a407cf0c4600a2f608fab5f516482023-06-18T11:15:11ZengNature PortfolioScientific Reports2045-23222023-06-0113111110.1038/s41598-023-37069-1Inflammatory-like status and acute stress response in horses after road transportFrancesca Arfuso0Maria Rizzo1Claudia Giannetto2Elisabetta Giudice3Giuseppe Piccione4Francesco Fazio5Roberta Cirincione6Giovanni Cassata7Luca Cicero8Department of Veterinary Sciences, University of MessinaDepartment of Veterinary Sciences, University of MessinaDepartment of Veterinary Sciences, University of MessinaDepartment of Veterinary Sciences, University of MessinaDepartment of Veterinary Sciences, University of MessinaDepartment of Veterinary Sciences, University of MessinaIstituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”Abstract This study aimed to evaluate the change of white blood cell count, serum concentration of cortisol, C-reactive protein, albumin and globulin fractions in horse after road transport, and to assess the linkage among hypothalamic–pituitary–adrenal axis (HPA) and inflammatory reaction. From 10 horses blood samples were collected at rest, before road transport (218 km) (BT); after unloaded (AT), 30 and 60 min after unloaded (AT30 and AT60) in order to assess white blood cell count (WBC), serum cortisol, C-reactive protein (CRP), total proteins, albumin, α1-, α-2, β1-, β2- and γ-globulins. WBC, cortisol, CRP, α1-, α-2 and β2-globulins values increased after road transport than rest condition (p < 0.001). Albumin and A/G ratio showed lower values after road transport than rest (p < 0.001). Pearson’s test showed a negative correlation between cortisol and the values of WBC, CRP, α1-, α2-, β1-, β2- globulins, and a positive correlation between WBC and serum concentration of CRP, α1- and α2-, β1-, β2-globulins at AT and AT30. The results showed that road transport evokes an inflammatory like-status in horses. Moreover, the activation of HPA and the onset of acute phase reaction in response to road transport seem to be interconnected with effects on horse’s immune status.https://doi.org/10.1038/s41598-023-37069-1 |
| spellingShingle | Francesca Arfuso Maria Rizzo Claudia Giannetto Elisabetta Giudice Giuseppe Piccione Francesco Fazio Roberta Cirincione Giovanni Cassata Luca Cicero Inflammatory-like status and acute stress response in horses after road transport Scientific Reports |
| title | Inflammatory-like status and acute stress response in horses after road transport |
| title_full | Inflammatory-like status and acute stress response in horses after road transport |
| title_fullStr | Inflammatory-like status and acute stress response in horses after road transport |
| title_full_unstemmed | Inflammatory-like status and acute stress response in horses after road transport |
| title_short | Inflammatory-like status and acute stress response in horses after road transport |
| title_sort | inflammatory like status and acute stress response in horses after road transport |
| url | https://doi.org/10.1038/s41598-023-37069-1 |
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