Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy
Abstract Background The analgesic and cardiorespiratory effects of ketamine, fentanyl, or ketamine-fentanyl constant rate infusion (CRI) in dogs undergoing mastectomy were evaluated. Seventeen female dogs received CRI of ketamine (GK [n = 6]: bolus 0.5 mg/kg; CRI 20 µg/kg/min in intra- and postopera...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-022-03244-1 |
| _version_ | 1811341613966819328 |
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| author | Rauane Sousa de Moura Isabela Plazza Bittar Janainne Hilbig Gomes Yan Victor Rodrigues de Oliveira Gladsthon Divino de Sousa Filho Glauco Cézar Fragola de Faria Soares Eliana Martins Lima Leandro Guimarães Franco |
| author_facet | Rauane Sousa de Moura Isabela Plazza Bittar Janainne Hilbig Gomes Yan Victor Rodrigues de Oliveira Gladsthon Divino de Sousa Filho Glauco Cézar Fragola de Faria Soares Eliana Martins Lima Leandro Guimarães Franco |
| author_sort | Rauane Sousa de Moura |
| collection | DOAJ |
| description | Abstract Background The analgesic and cardiorespiratory effects of ketamine, fentanyl, or ketamine-fentanyl constant rate infusion (CRI) in dogs undergoing mastectomy were evaluated. Seventeen female dogs received CRI of ketamine (GK [n = 6]: bolus 0.5 mg/kg; CRI 20 µg/kg/min in intra- and postoperative periods], fentanyl (GF [n = 5]: bolus 20 µg/kg; intraoperative CRI 5 20 µg/kg/hour and postoperative CRI 2 20 µg/kg/hour), or combination of ketamine-fentanyl (GKF [n = 6]: aforementioned doses) for 8 h. Cardiorespiratory, blood gas analyses, plasma drug concentrations, sedation score (SS), Pain Scores were evaluated. Results The heart rate decreased in the GF and GKF (p < 0.04); the mean arterial pressure was lower in the GKF than in the GK at 35 min (p < 0.001). Maximum plasma concentrations were observed 5 min after bolus in the GK (2847.06 ± 2903.03 ng/mL) and GKF (2811.20 ± 1931.76 ng/mL). Plasma concentration in intraoperative period of ketamine was of > 100 ng/mL in 5/5 and 2/5 animals in the GKF and GK, respectively; and > 1.1 ng/mL of fentanyl in 4/5 and 3/5 in GKF and GF, respectively. Conclusion Ketamine with/without fentanyl provided analgesia without significant cardiorespiratory and guaranteed the minimal plasma levels with analgesic potential during the 8 h. |
| first_indexed | 2024-04-13T18:58:04Z |
| format | Article |
| id | doaj.art-33d964ab0da245b0ba1768b7be7cbfd8 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-04-13T18:58:04Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-33d964ab0da245b0ba1768b7be7cbfd82022-12-22T02:34:11ZengBMCBMC Veterinary Research1746-61482022-06-0118111010.1186/s12917-022-03244-1Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomyRauane Sousa de Moura0Isabela Plazza Bittar1Janainne Hilbig Gomes2Yan Victor Rodrigues de Oliveira3Gladsthon Divino de Sousa Filho4Glauco Cézar Fragola de Faria Soares5Eliana Martins Lima6Leandro Guimarães Franco7Department of Veterinary Medicine, Federal University of GoiásDepartment of Veterinary Medicine, Federal University of GoiásDepartment of Veterinary Medicine, Federal University of GoiásDepartment of Veterinary Medicine, Federal University of GoiásDepartment of Veterinary Medicine, Federal University of GoiásDevelopment and Technological Innovation in Drugs - FarmaTec, Research Center, Universidade Federal de GoiásDevelopment and Technological Innovation in Drugs - FarmaTec, Research Center, Universidade Federal de GoiásDepartment of Veterinary Medicine, Federal University of GoiásAbstract Background The analgesic and cardiorespiratory effects of ketamine, fentanyl, or ketamine-fentanyl constant rate infusion (CRI) in dogs undergoing mastectomy were evaluated. Seventeen female dogs received CRI of ketamine (GK [n = 6]: bolus 0.5 mg/kg; CRI 20 µg/kg/min in intra- and postoperative periods], fentanyl (GF [n = 5]: bolus 20 µg/kg; intraoperative CRI 5 20 µg/kg/hour and postoperative CRI 2 20 µg/kg/hour), or combination of ketamine-fentanyl (GKF [n = 6]: aforementioned doses) for 8 h. Cardiorespiratory, blood gas analyses, plasma drug concentrations, sedation score (SS), Pain Scores were evaluated. Results The heart rate decreased in the GF and GKF (p < 0.04); the mean arterial pressure was lower in the GKF than in the GK at 35 min (p < 0.001). Maximum plasma concentrations were observed 5 min after bolus in the GK (2847.06 ± 2903.03 ng/mL) and GKF (2811.20 ± 1931.76 ng/mL). Plasma concentration in intraoperative period of ketamine was of > 100 ng/mL in 5/5 and 2/5 animals in the GKF and GK, respectively; and > 1.1 ng/mL of fentanyl in 4/5 and 3/5 in GKF and GF, respectively. Conclusion Ketamine with/without fentanyl provided analgesia without significant cardiorespiratory and guaranteed the minimal plasma levels with analgesic potential during the 8 h.https://doi.org/10.1186/s12917-022-03244-1AnalgesiaConstant rate infusionMechanical nociceptive thresholdPharmacokinetics |
| spellingShingle | Rauane Sousa de Moura Isabela Plazza Bittar Janainne Hilbig Gomes Yan Victor Rodrigues de Oliveira Gladsthon Divino de Sousa Filho Glauco Cézar Fragola de Faria Soares Eliana Martins Lima Leandro Guimarães Franco Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy BMC Veterinary Research Analgesia Constant rate infusion Mechanical nociceptive threshold Pharmacokinetics |
| title | Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy |
| title_full | Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy |
| title_fullStr | Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy |
| title_full_unstemmed | Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy |
| title_short | Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy |
| title_sort | plasma concentration cardiorespiratory and analgesic effects of ketamine fentanyl infusion in dogs submitted to mastectomy |
| topic | Analgesia Constant rate infusion Mechanical nociceptive threshold Pharmacokinetics |
| url | https://doi.org/10.1186/s12917-022-03244-1 |
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