A helminth-derived suppressor of ST2 blocks allergic responses

A helminth-derived suppressor of ST2 blocks allergic responses

The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoides polygyrus, which binds and blocks IL-33. Here, we identify H. polygyrus Binds Alarmin Receptor and Inhibits (HpBARI) and...

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Bibliographic Details
Main Authors: Francesco Vacca, Caroline Chauché, Abhishek Jamwal, Elizabeth C Hinchy, Graham Heieis, Holly Webster, Adefunke Ogunkanbi, Zala Sekne, William F Gregory, Martin Wear, Georgia Perona-Wright, Matthew K Higgins, Josquin A Nys, E Suzanne Cohen, Henry J McSorley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
allergy
asthma
Helminth
parasite
IL-33
ST2
Online Access:https://elifesciences.org/articles/54017

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