Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni
In this study, four compounds were utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1995-09-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000300003&lng=en&tlng=en |
| _version_ | 1811340714877911040 |
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| author | Paulo Marcos Zech Coelho Leógenes Horácio Pereira Rômulo Teixeira de Mello |
| author_facet | Paulo Marcos Zech Coelho Leógenes Horácio Pereira Rômulo Teixeira de Mello |
| author_sort | Paulo Marcos Zech Coelho |
| collection | DOAJ |
| description | In this study, four compounds were utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried out periodically, showed no viable eggs of the parasite, from day 29 to 226post-treatment. The perfusion undertaken after killing the animals showed absence of worms in the treated monkeys, whereas 83 worms were recovered from the control, thus corroborating the results obtained by means of oograms and coproscopy. These results confirm the efficacy of 9-acridanone- hydrazones previously tested against the LE strain of S. mansoni. The low curative dose and apparent absence of toxicity render these dmgs an important therapeutic reserve, taking into consideration the reports on the resistance of S. mansoni to the modern drugs oxamniquine and praziquantel. |
| first_indexed | 2024-04-13T18:46:01Z |
| format | Article |
| id | doaj.art-33dc8bf211e4434abef7c7c8bc4af2cb |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T18:46:01Z |
| publishDate | 1995-09-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-33dc8bf211e4434abef7c7c8bc4af2cb2022-12-22T02:34:35ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98491995-09-0128317918310.1590/S0037-86821995000300003S0037-86821995000300003Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoniPaulo Marcos Zech CoelhoLeógenes Horácio PereiraRômulo Teixeira de MelloIn this study, four compounds were utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried out periodically, showed no viable eggs of the parasite, from day 29 to 226post-treatment. The perfusion undertaken after killing the animals showed absence of worms in the treated monkeys, whereas 83 worms were recovered from the control, thus corroborating the results obtained by means of oograms and coproscopy. These results confirm the efficacy of 9-acridanone- hydrazones previously tested against the LE strain of S. mansoni. The low curative dose and apparent absence of toxicity render these dmgs an important therapeutic reserve, taking into consideration the reports on the resistance of S. mansoni to the modern drugs oxamniquine and praziquantel.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000300003&lng=en&tlng=enSchistosoma mansoniMacacos CebusAcridanona-hidrazonas |
| spellingShingle | Paulo Marcos Zech Coelho Leógenes Horácio Pereira Rômulo Teixeira de Mello Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni Revista da Sociedade Brasileira de Medicina Tropical Schistosoma mansoni Macacos Cebus Acridanona-hidrazonas |
| title | Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
| title_full | Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
| title_fullStr | Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
| title_full_unstemmed | Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
| title_short | Antischistosomal activity of acridanone- hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni |
| title_sort | antischistosomal activity of acridanone hydrazones in cebus monkeys experimentally infected with the sj strain of schistosoma mansoni |
| topic | Schistosoma mansoni Macacos Cebus Acridanona-hidrazonas |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000300003&lng=en&tlng=en |
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