Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats
Background: Moringa oleifera extract (Lam) has many antioxidant and protective properties. Objective: to investigate the antioxidant activities of Lam in counteracting the high oxidative stress caused by acute sub-lethal aluminium phosphide (AlP) intoxication in rat heart. These activities will be d...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Toxicology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750018300155 |
| _version_ | 1828881085569695744 |
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| author | Ahmed S. Gouda Nagla A. El-Nabarawy Samah F. Ibrahim |
| author_facet | Ahmed S. Gouda Nagla A. El-Nabarawy Samah F. Ibrahim |
| author_sort | Ahmed S. Gouda |
| collection | DOAJ |
| description | Background: Moringa oleifera extract (Lam) has many antioxidant and protective properties. Objective: to investigate the antioxidant activities of Lam in counteracting the high oxidative stress caused by acute sub-lethal aluminium phosphide (AlP) intoxication in rat heart. These activities will be detected by histopathological examination and some oxidative stress biomarkers. Methods: a single sub-lethal dose of Alp (2 mg/kg body weight) was administered orally, and Lam was given orally at a dose (100 mg/kg body weight) one hour after receiving AlP to rats. Results: aluminium phosphide caused significant cardiac histopathological changes with a significant increase in malondialdehyde (MDA); lipid peroxidation marker; and a significant depletion of antioxidant enzymes (catalase and glutathione reductase). However, treatment with Lam protected efficiently the cardiac tissue of intoxicated rats by increasing antioxidants levels with slight decreasing in MDA production compared to untreated group. Conclusions: This study suggested that Moringa oleifera extract could possibly restore the altered cardiac histopathology and some antioxidant power in AlP intoxicated rats, and it could even be used as adjuvant therapy against AlP-induced cardiotoxicity. Keywords: Toxicity, Aluminium phosphide, Cardiac toxicity, Oxidative stress, Moringa oleifera extract |
| first_indexed | 2024-12-13T10:00:56Z |
| format | Article |
| id | doaj.art-33deaeecf3c444f59346e4fca54bd8e8 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-13T10:00:56Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-33deaeecf3c444f59346e4fca54bd8e82022-12-21T23:51:40ZengElsevierToxicology Reports2214-75002018-01-015209212Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in ratsAhmed S. Gouda0Nagla A. El-Nabarawy1Samah F. Ibrahim2National Egyptian Center of Environmental and Toxicological Research, Faculty of Medicine, Cairo University, EgyptNational Egyptian Center of Environmental and Toxicological Research, Faculty of Medicine, Cairo University, EgyptForensic and Toxicology Department Faculty of Medicine, Cairo University, Egypt; Clinical Departement, Princess Nourah Bint Abdulrahman University, Riyadh, King Saudi Arabia; Corresponding author at: Faculty of Medicine, Cairo University, Egypt and Princess Nourah Bint Abdulrahman University, Riyadh, King Saudi Arabia.Background: Moringa oleifera extract (Lam) has many antioxidant and protective properties. Objective: to investigate the antioxidant activities of Lam in counteracting the high oxidative stress caused by acute sub-lethal aluminium phosphide (AlP) intoxication in rat heart. These activities will be detected by histopathological examination and some oxidative stress biomarkers. Methods: a single sub-lethal dose of Alp (2 mg/kg body weight) was administered orally, and Lam was given orally at a dose (100 mg/kg body weight) one hour after receiving AlP to rats. Results: aluminium phosphide caused significant cardiac histopathological changes with a significant increase in malondialdehyde (MDA); lipid peroxidation marker; and a significant depletion of antioxidant enzymes (catalase and glutathione reductase). However, treatment with Lam protected efficiently the cardiac tissue of intoxicated rats by increasing antioxidants levels with slight decreasing in MDA production compared to untreated group. Conclusions: This study suggested that Moringa oleifera extract could possibly restore the altered cardiac histopathology and some antioxidant power in AlP intoxicated rats, and it could even be used as adjuvant therapy against AlP-induced cardiotoxicity. Keywords: Toxicity, Aluminium phosphide, Cardiac toxicity, Oxidative stress, Moringa oleifera extracthttp://www.sciencedirect.com/science/article/pii/S2214750018300155 |
| spellingShingle | Ahmed S. Gouda Nagla A. El-Nabarawy Samah F. Ibrahim Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats Toxicology Reports |
| title | Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats |
| title_full | Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats |
| title_fullStr | Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats |
| title_full_unstemmed | Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats |
| title_short | Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats |
| title_sort | moringa oleifera extract lam attenuates aluminium phosphide induced acute cardiac toxicity in rats |
| url | http://www.sciencedirect.com/science/article/pii/S2214750018300155 |
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