Idiopathic longitudinally extensive myelitis: a brief historical excursion (review) and own clinical observation
Background: Idiopathic longitudinally extensive transverse myelitis is defined as a focal spinal cord lesion that involves three or more segments of the spinal cord as shown by neuroimaging, and results in a profound disability. The clinical picture of a patient with idiopathic longitudinally advanc...
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| Format: | Article |
| Language: | English |
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Eco-vector
2022-04-01
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| Series: | Клиническая практика |
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| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/100341/pdf |
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| author | Saule T. Turuspekova Klara K. Almakhanova Erkin S. Nurguzhaev Roza B. Nurzhanova Bayan K. Demesinova Togzhan Zh. Mukasheva Nikolay V. Stepuk |
| author_facet | Saule T. Turuspekova Klara K. Almakhanova Erkin S. Nurguzhaev Roza B. Nurzhanova Bayan K. Demesinova Togzhan Zh. Mukasheva Nikolay V. Stepuk |
| author_sort | Saule T. Turuspekova |
| collection | DOAJ |
| description | Background: Idiopathic longitudinally extensive transverse myelitis is defined as a focal spinal cord lesion that involves three or more segments of the spinal cord as shown by neuroimaging, and results in a profound disability. The clinical picture of a patient with idiopathic longitudinally advanced transverse myelitis is often dramatic and may consist of paraparesis or tetraparesis, sensory disturbances, and pelvic dysfunction. Idiopathic longitudinally advanced transverse myelitis is a common manifestation of the neuromyelitis optica spectrum disorders, but can also occur in various other autoimmune and inflammatory diseases of the CNS, such as multiple sclerosis, sarcoidosis, or Sjogrens syndrome, or in infectious diseases involving the CNS. It is less likely to occur in isolation, as the only manifestation of a demyelinating disease of the nervous system of an unknown etiology (idiopathic myelitis).
Clinical case description: The clinical observation presented in the article demonstrates the difficulties of establishing a nosological diagnosis in the case of a monophasic course of TM in the absence of other autoimmune and infectious diseases of the central nervous system. The patient with idiopathic longitudinally distributed TM had no visual disturbances and no antibodies to aquaporin 4 and to myelin oligodendrocyte glycoprotein (MOG-IgG) with twice repeated tests.
Conclusion: In this regard, it is important to dynamically monitor the clinical manifestations and MRI signs in patients with an isolated lesion of a demyelinating nature in the form of longitudinally extensive transverse myelitis. |
| first_indexed | 2024-03-12T06:35:53Z |
| format | Article |
| id | doaj.art-33df9c9a48f54bedbb35ce4831e13c11 |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-03-12T06:35:53Z |
| publishDate | 2022-04-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-33df9c9a48f54bedbb35ce4831e13c112023-09-03T01:17:16ZengEco-vectorКлиническая практика2220-30952618-86272022-04-0113112312810.17816/clinpract10034178308Idiopathic longitudinally extensive myelitis: a brief historical excursion (review) and own clinical observationSaule T. Turuspekova0https://orcid.org/0000-0002-4593-3053Klara K. Almakhanova1https://orcid.org/0000-0002-0498-0566Erkin S. Nurguzhaev2https://orcid.org/0000-0001-8110-9013Roza B. Nurzhanova3https://orcid.org/0000-0001-8838-8107Bayan K. Demesinova4https://orcid.org/0000-0002-7302-6178Togzhan Zh. Mukasheva5https://orcid.org/0000-0002-0471-4137Nikolay V. Stepuk6https://orcid.org/0000-0003-3750-0546Аsfendiyarov Kazakh National Medical UniversityАsfendiyarov Kazakh National Medical UniversityАsfendiyarov Kazakh National Medical UniversityАsfendiyarov Kazakh National Medical UniversityАsfendiyarov Kazakh National Medical University1st City Hospital1st City HospitalBackground: Idiopathic longitudinally extensive transverse myelitis is defined as a focal spinal cord lesion that involves three or more segments of the spinal cord as shown by neuroimaging, and results in a profound disability. The clinical picture of a patient with idiopathic longitudinally advanced transverse myelitis is often dramatic and may consist of paraparesis or tetraparesis, sensory disturbances, and pelvic dysfunction. Idiopathic longitudinally advanced transverse myelitis is a common manifestation of the neuromyelitis optica spectrum disorders, but can also occur in various other autoimmune and inflammatory diseases of the CNS, such as multiple sclerosis, sarcoidosis, or Sjogrens syndrome, or in infectious diseases involving the CNS. It is less likely to occur in isolation, as the only manifestation of a demyelinating disease of the nervous system of an unknown etiology (idiopathic myelitis). Clinical case description: The clinical observation presented in the article demonstrates the difficulties of establishing a nosological diagnosis in the case of a monophasic course of TM in the absence of other autoimmune and infectious diseases of the central nervous system. The patient with idiopathic longitudinally distributed TM had no visual disturbances and no antibodies to aquaporin 4 and to myelin oligodendrocyte glycoprotein (MOG-IgG) with twice repeated tests. Conclusion: In this regard, it is important to dynamically monitor the clinical manifestations and MRI signs in patients with an isolated lesion of a demyelinating nature in the form of longitudinally extensive transverse myelitis.https://journals.eco-vector.com/clinpractice/article/viewFile/100341/pdftransverse myelitisneuromyelitis optica spectrum disorderaquaporin 4antibodies to myelin oligodendrocyte glycoproteinclinical observationfemale |
| spellingShingle | Saule T. Turuspekova Klara K. Almakhanova Erkin S. Nurguzhaev Roza B. Nurzhanova Bayan K. Demesinova Togzhan Zh. Mukasheva Nikolay V. Stepuk Idiopathic longitudinally extensive myelitis: a brief historical excursion (review) and own clinical observation Клиническая практика transverse myelitis neuromyelitis optica spectrum disorder aquaporin 4 antibodies to myelin oligodendrocyte glycoprotein clinical observation female |
| title | Idiopathic longitudinally extensive myelitis: a brief historical excursion (review) and own clinical observation |
| title_full | Idiopathic longitudinally extensive myelitis: a brief historical excursion (review) and own clinical observation |
| title_fullStr | Idiopathic longitudinally extensive myelitis: a brief historical excursion (review) and own clinical observation |
| title_full_unstemmed | Idiopathic longitudinally extensive myelitis: a brief historical excursion (review) and own clinical observation |
| title_short | Idiopathic longitudinally extensive myelitis: a brief historical excursion (review) and own clinical observation |
| title_sort | idiopathic longitudinally extensive myelitis a brief historical excursion review and own clinical observation |
| topic | transverse myelitis neuromyelitis optica spectrum disorder aquaporin 4 antibodies to myelin oligodendrocyte glycoprotein clinical observation female |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/100341/pdf |
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