A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells

A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells

Abstract Background Tumor cells have the ability to invade and form small clusters that protrude into adjacent tissues, a phenomenon that is frequently observed at the periphery of a tumor as it expands into healthy tissues. The presence of these clusters is linked to poor prognosis and has proven c...

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Bibliographic Details
Main Authors: Pedro Fonseca, Weiyingqi Cui, Nona Struyf, Le Tong, Ayushi Chaurasiya, Felipe Casagrande, Honglei Zhao, Dinura Fernando, Xinsong Chen, Nicholas P. Tobin, Brinton Seashore-Ludlow, Andreas Lundqvist, Johan Hartman, Anita Göndör, Päivi Östling, Lars Holmgren
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer
Cancer invasion
Metastasis
Mechanotransduction
Phenotypic drug screening
Patient-derived organoids
Online Access:https://doi.org/10.1186/s13046-024-03031-w

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