Administration of Bacteriophages via Nebulization during Mechanical Ventilation: In Vitro Study and Lung Deposition in Macaques

Administration of Bacteriophages via Nebulization during Mechanical Ventilation: In Vitro Study and Lung Deposition in Macaques

Bacteriophages have been identified as a potential treatment option to treat lung infection in the context of antibiotic resistance. We performed a preclinical study to predict the efficacy of delivery of bacteriophages against <i>Pseudomonas aeruginosa</i> (PA) when administered via neb...

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Bibliographic Details
Main Authors: Sandrine Le Guellec, Jeoffrey Pardessus, Elsa Bodier-Montagutelli, Guillaume L’Hostis, Emilie Dalloneau, Damien Piel, Hakim Chouky Samaï, Antoine Guillon, Elvir Mujic, Emmanuelle Guillot-Combe, Stephan Ehrmann, Eric Morello, Jérôme Gabard, Nathalie Heuzé-Vourc’h, Cindy Fevre, Laurent Vecellio
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Viruses
Subjects:
bacteriophages
nebulization
morphotype
in vitro viability
mechanical ventilation
in vivo aerosol deposition
Online Access:https://www.mdpi.com/1999-4915/15/3/602

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