Collagen Cross-linking in Keratoconus Patients with Thin Corneas: Short-Term Results
Pur po se: To study the effectiveness and safety of corneal collagen cross-linking with hypoosmolar riboflavin solution applied to keratoconus patients with thin corneas. Ma te ri al and Met hod: In this retrospective study, medical records of keratoconus patients planned for cross-linking surgery...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2012-10-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.oftalmoloji.org/article_2183/Collagen-Cross-linking-In-Keratoconus-Patients-With-Thin-Corneas-Short-term-Results |
| Summary: | Pur po se: To study the effectiveness and safety of corneal collagen cross-linking with hypoosmolar riboflavin solution applied to
keratoconus patients with thin corneas.
Ma te ri al and Met hod: In this retrospective study, medical records of keratoconus patients planned for cross-linking surgery and
having thinnest corneal thickness (TCT) less than 400 μm after corneal epithelial removal were reviewed. There were 12 patients and
16 eyes in the study cohort. After the epithelium was removed, hypoosmolar solution was applied for 30 minutes and pachymetric
measurements were taken. If corneal thickness became more than 400 μm, the cross-linking procedure was started; if not, hypoosmolar
solution was continued until corneal thickness reached 400 μm. Maximum keratometry values (K Max), pachymetric measurements,
uncorrected distance visual acuities (UDVA), and corrected distance visual acuities (CDVA) were recorded. Comparison between
preoperative measurements and measurements taken in sixth postoperative month were performed.
Re sults: The mean TCT was 422.75±26.98 μm preoperatively (max: 450, min: 360). The mean TCT was reduced to 373.63±22.41 μm after
epithelium was removed (max: 398, min: 325). There was a statistically significant difference between preoperative K max (62.62±5.09) and
postoperative K max (61.55±5.80), (p=0.03). On the other hand, the difference between preoperative-postoperative UDVA (p=0.29) and
preoperative-postoperative CDVA was not significant (p=058). There were no cases with significant corneal opacity or with any other complication.
Dis cus si on: Corneal collagen cross-linking with hypoosmolar riboflavin solution in keratoconus patients with thin corneas is an effective
procedure and can be considered as safe regarding preservation of visual acuities and absence of significant corneal opacity. (Turk J
Ophthalmol 2012; 42: 316-20 |
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| ISSN: | 1300-0659 2147-2661 |