Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors

Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors

Abstract Nucleotide repeat expansion of GGGGCC (G4C2) in the non-coding region of C9orf72 is the most common genetic cause underlying amyotrophic lateral sclerosis and frontotemporal dementia. Transcripts harboring this repeat expansion undergo the translation of dipeptide repeats via a non-canonica...

Full description

Bibliographic Details
Main Authors: Hayato Ito, Kodai Machida, Mayuka Hasumi, Morio Ueyama, Yoshitaka Nagai, Hiroaki Imataka, Hideki Taguchi
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-50188-z

Similar Items

Similar Items