Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice
Abstract Spinal cord injury (SCI) is a destructive traumatic disease of the central nervous system without satisfying therapy efficiency. Bone marrow mesenchymal stem cells (BMMSCs) therapy promotes the neurotrophic factors’ secretion and axonal regeneration, thereby promoting recovery of SCI. Pulse...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.160 |
| _version_ | 1798036635196063744 |
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| author | Liyi Huang Xin Sun Lu Wang Gaiqing Pei Yang Wang Qing Zhang Zejun Liang Dong Wang Chenying Fu Chengqi He Quan Wei |
| author_facet | Liyi Huang Xin Sun Lu Wang Gaiqing Pei Yang Wang Qing Zhang Zejun Liang Dong Wang Chenying Fu Chengqi He Quan Wei |
| author_sort | Liyi Huang |
| collection | DOAJ |
| description | Abstract Spinal cord injury (SCI) is a destructive traumatic disease of the central nervous system without satisfying therapy efficiency. Bone marrow mesenchymal stem cells (BMMSCs) therapy promotes the neurotrophic factors’ secretion and axonal regeneration, thereby promoting recovery of SCI. Pulsed electromagnetic fields (PEMF) therapy has been proven to promote neural growth and regeneration. Both BMMSCs and PEMF have shown curative effects for SCI; PEMF can further promote stem cell differentiation. Thus, we explored the combined effects of BMMSCs and PEMF and the potential interaction between these two therapies in SCI. Compared with the SCI control, BMMSCs, and PEMF groups, the combinational therapy displayed the best therapeutic effect. Combinational therapy increased the expression levels of nutritional factors including brain‐derived neurotrophic factor (BDNF), nerve growth factors (NGF) and vascular endothelial growth factor (VEGF), enhanced neuron preservation (NeuN and NF‐200), and increased axonal growth (MBP and myelin sheath). Additionally, PEMF promoted the expression levels of BDNF and VEGF in BMMSCs via Wnt/β‐catenin signaling pathway. In summary, the combined therapy of BMMSCs and PEMF displayed a more satisfactory effect than BMMSCs and PEMF therapy alone, indicating a promising application of combined therapy for the therapy of SCI. |
| first_indexed | 2024-04-11T21:15:38Z |
| format | Article |
| id | doaj.art-33e6cb421f584bab886d0100aa73187a |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-04-11T21:15:38Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-33e6cb421f584bab886d0100aa73187a2022-12-22T04:02:50ZengWileyMedComm2688-26632022-09-0133n/an/a10.1002/mco2.160Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in miceLiyi Huang0Xin Sun1Lu Wang2Gaiqing Pei3Yang Wang4Qing Zhang5Zejun Liang6Dong Wang7Chenying Fu8Chengqi He9Quan Wei10Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaNational Clinical Research Center for Geriatrics, West China Hospital Sichuan University Chengdu Sichuan PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital Sichuan University Chengdu PR ChinaAbstract Spinal cord injury (SCI) is a destructive traumatic disease of the central nervous system without satisfying therapy efficiency. Bone marrow mesenchymal stem cells (BMMSCs) therapy promotes the neurotrophic factors’ secretion and axonal regeneration, thereby promoting recovery of SCI. Pulsed electromagnetic fields (PEMF) therapy has been proven to promote neural growth and regeneration. Both BMMSCs and PEMF have shown curative effects for SCI; PEMF can further promote stem cell differentiation. Thus, we explored the combined effects of BMMSCs and PEMF and the potential interaction between these two therapies in SCI. Compared with the SCI control, BMMSCs, and PEMF groups, the combinational therapy displayed the best therapeutic effect. Combinational therapy increased the expression levels of nutritional factors including brain‐derived neurotrophic factor (BDNF), nerve growth factors (NGF) and vascular endothelial growth factor (VEGF), enhanced neuron preservation (NeuN and NF‐200), and increased axonal growth (MBP and myelin sheath). Additionally, PEMF promoted the expression levels of BDNF and VEGF in BMMSCs via Wnt/β‐catenin signaling pathway. In summary, the combined therapy of BMMSCs and PEMF displayed a more satisfactory effect than BMMSCs and PEMF therapy alone, indicating a promising application of combined therapy for the therapy of SCI.https://doi.org/10.1002/mco2.160bone marrow mesenchymal stem cellsmotor functional recoverynutritional factorspulsed electromagnetic fieldsspinal cord injury |
| spellingShingle | Liyi Huang Xin Sun Lu Wang Gaiqing Pei Yang Wang Qing Zhang Zejun Liang Dong Wang Chenying Fu Chengqi He Quan Wei Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice MedComm bone marrow mesenchymal stem cells motor functional recovery nutritional factors pulsed electromagnetic fields spinal cord injury |
| title | Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice |
| title_full | Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice |
| title_fullStr | Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice |
| title_full_unstemmed | Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice |
| title_short | Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice |
| title_sort | enhanced effect of combining bone marrow mesenchymal stem cells bmmscs and pulsed electromagnetic fields pemf to promote recovery after spinal cord injury in mice |
| topic | bone marrow mesenchymal stem cells motor functional recovery nutritional factors pulsed electromagnetic fields spinal cord injury |
| url | https://doi.org/10.1002/mco2.160 |
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