Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy
With the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed via a free radical mechanism could be used to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/11/2206 |
| _version_ | 1827647421106094080 |
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| author | InWha Park Goeun Park Yoojin Choi Seung-Woo Jo Hak Cheol Kwon Jin-Soo Park Jin Wook Cha |
| author_facet | InWha Park Goeun Park Yoojin Choi Seung-Woo Jo Hak Cheol Kwon Jin-Soo Park Jin Wook Cha |
| author_sort | InWha Park |
| collection | DOAJ |
| description | With the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed via a free radical mechanism could be used to modulate the radical-scavenging ability of natural products as well as involve structural change. As the health benefits of radicals are also presented, there is a need for a controllable radical scavenging method for topical and selective application. In this study, we developed a novel acquisition and processing method to identify light-controlled radical scavengers in plant extracts and evaluate their antioxidant activity under light irradiation based on in situ UV-LED NMR spectroscopy. Using the developed method, licochalcones A and B, in which the <i>trans</i> and <i>cis</i> isomers undergo reversible photoisomerization, were selectively identified from licorice root extract, and their light-induced free radical scavenging activity was confirmed. |
| first_indexed | 2024-03-09T19:18:54Z |
| format | Article |
| id | doaj.art-33e719a3ce4b45b2857be1c7ca056d22 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T19:18:54Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-33e719a3ce4b45b2857be1c7ca056d222023-11-24T03:30:58ZengMDPI AGAntioxidants2076-39212022-11-011111220610.3390/antiox11112206Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR SpectroscopyInWha Park0Goeun Park1Yoojin Choi2Seung-Woo Jo3Hak Cheol Kwon4Jin-Soo Park5Jin Wook Cha6Natural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, KoreaNatural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, KoreaNatural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, KoreaNatural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, KoreaNatural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, KoreaNatural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, KoreaNatural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, KoreaWith the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed via a free radical mechanism could be used to modulate the radical-scavenging ability of natural products as well as involve structural change. As the health benefits of radicals are also presented, there is a need for a controllable radical scavenging method for topical and selective application. In this study, we developed a novel acquisition and processing method to identify light-controlled radical scavengers in plant extracts and evaluate their antioxidant activity under light irradiation based on in situ UV-LED NMR spectroscopy. Using the developed method, licochalcones A and B, in which the <i>trans</i> and <i>cis</i> isomers undergo reversible photoisomerization, were selectively identified from licorice root extract, and their light-induced free radical scavenging activity was confirmed.https://www.mdpi.com/2076-3921/11/11/2206free radical scavengerin situ NMR spectroscopynatural productsphotoisomerization |
| spellingShingle | InWha Park Goeun Park Yoojin Choi Seung-Woo Jo Hak Cheol Kwon Jin-Soo Park Jin Wook Cha Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy Antioxidants free radical scavenger in situ NMR spectroscopy natural products photoisomerization |
| title | Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy |
| title_full | Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy |
| title_fullStr | Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy |
| title_full_unstemmed | Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy |
| title_short | Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy |
| title_sort | facile detection of light controlled radical scavengers from natural products using in situ uv led nmr spectroscopy |
| topic | free radical scavenger in situ NMR spectroscopy natural products photoisomerization |
| url | https://www.mdpi.com/2076-3921/11/11/2206 |
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