Botulinum Neurotoxin Injections in Childhood Opisthotonus
Opisthotonus refers to abnormal axial extension and arching of the trunk produced by excessive contractions of the paraspinal muscles. In childhood, the abnormal posture is most often related to dystonia in the setting of hypoxic injury or a number of other acquired and genetic etiologies. The condi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/2/137 |
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| author | Mariam Hull Mered Parnes Joseph Jankovic |
| author_facet | Mariam Hull Mered Parnes Joseph Jankovic |
| author_sort | Mariam Hull |
| collection | DOAJ |
| description | Opisthotonus refers to abnormal axial extension and arching of the trunk produced by excessive contractions of the paraspinal muscles. In childhood, the abnormal posture is most often related to dystonia in the setting of hypoxic injury or a number of other acquired and genetic etiologies. The condition is often painful, interferes with ambulation and quality of life, and is challenging to treat. Therapeutic options include oral benzodiazepines, oral and intrathecal baclofen, botulinum neurotoxin injections, and deep brain stimulation. Management of opisthotonus within the pediatric population has not been systematically reviewed. Here, we describe a series of seven children who presented to our institution with opisthotonus in whom symptom relief was achieved following administration of botulinum neurotoxin injections. |
| first_indexed | 2024-03-09T00:55:22Z |
| format | Article |
| id | doaj.art-33e78da4bfb74294959619dfcd987ce2 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T00:55:22Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-33e78da4bfb74294959619dfcd987ce22023-12-11T16:56:15ZengMDPI AGToxins2072-66512021-02-0113213710.3390/toxins13020137Botulinum Neurotoxin Injections in Childhood OpisthotonusMariam Hull0Mered Parnes1Joseph Jankovic2Section of Pediatric Neurology and Developmental Neuroscience, Texas Children’s Hospital and Baylor College of Medicine, Houston, TX 77030, USASection of Pediatric Neurology and Developmental Neuroscience, Texas Children’s Hospital and Baylor College of Medicine, Houston, TX 77030, USAParkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USAOpisthotonus refers to abnormal axial extension and arching of the trunk produced by excessive contractions of the paraspinal muscles. In childhood, the abnormal posture is most often related to dystonia in the setting of hypoxic injury or a number of other acquired and genetic etiologies. The condition is often painful, interferes with ambulation and quality of life, and is challenging to treat. Therapeutic options include oral benzodiazepines, oral and intrathecal baclofen, botulinum neurotoxin injections, and deep brain stimulation. Management of opisthotonus within the pediatric population has not been systematically reviewed. Here, we describe a series of seven children who presented to our institution with opisthotonus in whom symptom relief was achieved following administration of botulinum neurotoxin injections.https://www.mdpi.com/2072-6651/13/2/137opisthotonusopisthotonosaxial dystoniabotulinum toxin |
| spellingShingle | Mariam Hull Mered Parnes Joseph Jankovic Botulinum Neurotoxin Injections in Childhood Opisthotonus Toxins opisthotonus opisthotonos axial dystonia botulinum toxin |
| title | Botulinum Neurotoxin Injections in Childhood Opisthotonus |
| title_full | Botulinum Neurotoxin Injections in Childhood Opisthotonus |
| title_fullStr | Botulinum Neurotoxin Injections in Childhood Opisthotonus |
| title_full_unstemmed | Botulinum Neurotoxin Injections in Childhood Opisthotonus |
| title_short | Botulinum Neurotoxin Injections in Childhood Opisthotonus |
| title_sort | botulinum neurotoxin injections in childhood opisthotonus |
| topic | opisthotonus opisthotonos axial dystonia botulinum toxin |
| url | https://www.mdpi.com/2072-6651/13/2/137 |
| work_keys_str_mv | AT mariamhull botulinumneurotoxininjectionsinchildhoodopisthotonus AT meredparnes botulinumneurotoxininjectionsinchildhoodopisthotonus AT josephjankovic botulinumneurotoxininjectionsinchildhoodopisthotonus |