Improving the "real life" management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services.
Schizophrenia poses a significant economic burden on the healthcare system as well as it has a significant impact on society at large. Reasons for such a high economic burden of schizophrenia include the frequent relapses and hospitalizations occurring in this disorder. We analyze the effectiveness...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0230051 |
| _version_ | 1818586726256345088 |
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| author | Valeria Latorre Apostolos Papazacharias Maria Lorusso Gaetano Nappi Paola Clemente Antonia Spinelli Giovanni Carrieri Enrico D'Ambrosio Michele Gattullo Antonio Emmanuele Uva Domenico Semisa |
| author_facet | Valeria Latorre Apostolos Papazacharias Maria Lorusso Gaetano Nappi Paola Clemente Antonia Spinelli Giovanni Carrieri Enrico D'Ambrosio Michele Gattullo Antonio Emmanuele Uva Domenico Semisa |
| author_sort | Valeria Latorre |
| collection | DOAJ |
| description | Schizophrenia poses a significant economic burden on the healthcare system as well as it has a significant impact on society at large. Reasons for such a high economic burden of schizophrenia include the frequent relapses and hospitalizations occurring in this disorder. We analyze the effectiveness of long-acting injectable antipsychotics (LAIs) compared to oral medications, in terms of "clinical process management" in a sample of patients with a diagnosis of schizophrenia spectrum disorder treated in community mental health centers. An observational, retrospective, mirror-image study was carried out to evaluate the effectiveness of LAIs compared to oral medications in terms of number of hospitalizations, emergency visits and planned visits on a 10-year period (from July 2007 to June 2017). Differences between first and second generation LAIs were also explored. Our findings show that hospitalization and emergency visits are significantly decreased with the use of LAIs, while planned visits are increased in patients treated with LAIs. Our results suggest that LAIs, in particular, second generation ones, reduce hospitalization rates and emergency visits, improving the economic burden of schizophrenia. Therefore, LAIs should be considered a cost-effective treatment in the management of schizophrenia under routine conditions. |
| first_indexed | 2024-12-16T08:57:32Z |
| format | Article |
| id | doaj.art-33e86fa3745d446db137291aadd05568 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T08:57:32Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-33e86fa3745d446db137291aadd055682022-12-21T22:37:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01153e023005110.1371/journal.pone.0230051Improving the "real life" management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services.Valeria LatorreApostolos PapazachariasMaria LorussoGaetano NappiPaola ClementeAntonia SpinelliGiovanni CarrieriEnrico D'AmbrosioMichele GattulloAntonio Emmanuele UvaDomenico SemisaSchizophrenia poses a significant economic burden on the healthcare system as well as it has a significant impact on society at large. Reasons for such a high economic burden of schizophrenia include the frequent relapses and hospitalizations occurring in this disorder. We analyze the effectiveness of long-acting injectable antipsychotics (LAIs) compared to oral medications, in terms of "clinical process management" in a sample of patients with a diagnosis of schizophrenia spectrum disorder treated in community mental health centers. An observational, retrospective, mirror-image study was carried out to evaluate the effectiveness of LAIs compared to oral medications in terms of number of hospitalizations, emergency visits and planned visits on a 10-year period (from July 2007 to June 2017). Differences between first and second generation LAIs were also explored. Our findings show that hospitalization and emergency visits are significantly decreased with the use of LAIs, while planned visits are increased in patients treated with LAIs. Our results suggest that LAIs, in particular, second generation ones, reduce hospitalization rates and emergency visits, improving the economic burden of schizophrenia. Therefore, LAIs should be considered a cost-effective treatment in the management of schizophrenia under routine conditions.https://doi.org/10.1371/journal.pone.0230051 |
| spellingShingle | Valeria Latorre Apostolos Papazacharias Maria Lorusso Gaetano Nappi Paola Clemente Antonia Spinelli Giovanni Carrieri Enrico D'Ambrosio Michele Gattullo Antonio Emmanuele Uva Domenico Semisa Improving the "real life" management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services. PLoS ONE |
| title | Improving the "real life" management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services. |
| title_full | Improving the "real life" management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services. |
| title_fullStr | Improving the "real life" management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services. |
| title_full_unstemmed | Improving the "real life" management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services. |
| title_short | Improving the "real life" management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services. |
| title_sort | improving the real life management of schizophrenia spectrum disorders by lai antipsychotics a one year mirror image retrospective study in community mental health services |
| url | https://doi.org/10.1371/journal.pone.0230051 |
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