INTENSIVE THERAPY OF THE ENDOGENOUS INTOXICATION SYNDROME IN PATIENTS WITH SEVERE BURNS
BACKGROUND. Severe burns are accompanied by the development of endogenous intoxication syndrome. Endogenous intoxication syndrome (EIS) is thus specified as a complex of severe clinical aspects with detoxification systems failure — in other words, the syndrome of multi-organ failure (MOFS) or ineffi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2016-02-01
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| Series: | Неотложная медицинская помощь |
| Subjects: | |
| Online Access: | https://www.jnmp.ru/jour/article/view/7 |
| _version_ | 1797705109524709376 |
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| author | N. M. Shulayeva E. V. Kuspits V. V. Schukovsky N. V. Ostrovsky |
| author_facet | N. M. Shulayeva E. V. Kuspits V. V. Schukovsky N. V. Ostrovsky |
| author_sort | N. M. Shulayeva |
| collection | DOAJ |
| description | BACKGROUND. Severe burns are accompanied by the development of endogenous intoxication syndrome. Endogenous intoxication syndrome (EIS) is thus specified as a complex of severe clinical aspects with detoxification systems failure — in other words, the syndrome of multi-organ failure (MOFS) or inefficiency, depending on severity of EIS (compensation, subcompensation, decompensation) [1, 2].PURPOSE. To improve the results of EIS and MOFS treatment in the patients with severe burns by including into medication succinic acid-based anti-oxidants combined with hepatoprotectors of the ademetionine group.MATERIAL AND METHODS. We carried out analysis of complex examination and treatment of 108 patients aged 18–50 with severe thermal injury, total burn area (S) ≥40%, and severity index ≥90.RESULTS. The use of succinic acid-based anti-oxidants within the framework of antishock and disintoxication therapy, later combined with hepatoprotectors of the ademetionine group, decreases the intensity of endogenous intoxication and multi-organ failure syndrome.CONCLUSION. To treat endotoxemia and multiple organ dysfunction caused by oxidative stress and hypoxia in patients with severe and extremely severe burns, it is appropriate to prescribe succinic acid-based anti-oxidants. To prevent albumen synthesis and detoxication hepar dysfunctions, decrease the manifestations of endotoxemia, and complement the cytoprotective action of succinic acid-based antioxidants, it is appropriate to prescribe hepatoprotectors. |
| first_indexed | 2024-03-12T05:30:35Z |
| format | Article |
| id | doaj.art-33e894fa51c64230aeb34a2c2742df6a |
| institution | Directory Open Access Journal |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| last_indexed | 2024-03-12T05:30:35Z |
| publishDate | 2016-02-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj.art-33e894fa51c64230aeb34a2c2742df6a2023-09-03T06:53:52ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172016-02-010127326INTENSIVE THERAPY OF THE ENDOGENOUS INTOXICATION SYNDROME IN PATIENTS WITH SEVERE BURNSN. M. Shulayeva0E. V. Kuspits1V. V. Schukovsky2N. V. Ostrovsky3City Clinical Hospital N. 7, SaratovCity Clinical Hospital N. 7, SaratovCity Clinical Hospital N. 7, SaratovCity Clinical Hospital N. 7, SaratovBACKGROUND. Severe burns are accompanied by the development of endogenous intoxication syndrome. Endogenous intoxication syndrome (EIS) is thus specified as a complex of severe clinical aspects with detoxification systems failure — in other words, the syndrome of multi-organ failure (MOFS) or inefficiency, depending on severity of EIS (compensation, subcompensation, decompensation) [1, 2].PURPOSE. To improve the results of EIS and MOFS treatment in the patients with severe burns by including into medication succinic acid-based anti-oxidants combined with hepatoprotectors of the ademetionine group.MATERIAL AND METHODS. We carried out analysis of complex examination and treatment of 108 patients aged 18–50 with severe thermal injury, total burn area (S) ≥40%, and severity index ≥90.RESULTS. The use of succinic acid-based anti-oxidants within the framework of antishock and disintoxication therapy, later combined with hepatoprotectors of the ademetionine group, decreases the intensity of endogenous intoxication and multi-organ failure syndrome.CONCLUSION. To treat endotoxemia and multiple organ dysfunction caused by oxidative stress and hypoxia in patients with severe and extremely severe burns, it is appropriate to prescribe succinic acid-based anti-oxidants. To prevent albumen synthesis and detoxication hepar dysfunctions, decrease the manifestations of endotoxemia, and complement the cytoprotective action of succinic acid-based antioxidants, it is appropriate to prescribe hepatoprotectors.https://www.jnmp.ru/jour/article/view/7burnsendogenous intoxicationmultiple organ dysfunction |
| spellingShingle | N. M. Shulayeva E. V. Kuspits V. V. Schukovsky N. V. Ostrovsky INTENSIVE THERAPY OF THE ENDOGENOUS INTOXICATION SYNDROME IN PATIENTS WITH SEVERE BURNS Неотложная медицинская помощь burns endogenous intoxication multiple organ dysfunction |
| title | INTENSIVE THERAPY OF THE ENDOGENOUS INTOXICATION SYNDROME IN PATIENTS WITH SEVERE BURNS |
| title_full | INTENSIVE THERAPY OF THE ENDOGENOUS INTOXICATION SYNDROME IN PATIENTS WITH SEVERE BURNS |
| title_fullStr | INTENSIVE THERAPY OF THE ENDOGENOUS INTOXICATION SYNDROME IN PATIENTS WITH SEVERE BURNS |
| title_full_unstemmed | INTENSIVE THERAPY OF THE ENDOGENOUS INTOXICATION SYNDROME IN PATIENTS WITH SEVERE BURNS |
| title_short | INTENSIVE THERAPY OF THE ENDOGENOUS INTOXICATION SYNDROME IN PATIENTS WITH SEVERE BURNS |
| title_sort | intensive therapy of the endogenous intoxication syndrome in patients with severe burns |
| topic | burns endogenous intoxication multiple organ dysfunction |
| url | https://www.jnmp.ru/jour/article/view/7 |
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