Anti-Melanogenic and Antioxidant Activity of <i>Bifidobacterium longum</i> Strain ZJ1 Extracts, Isolated from a Chinese Centenarian
Melanin produced by melanocytes protects our skin against ultraviolet (UV) radiation-induced cell damage and oxidative stress. Melanin overproduction by hyperactivated melanocytes is the direct cause of skin hyperpigmentary disorders, such as freckles and melasma. Exploring natural whitening agents...
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MDPI AG
2023-08-01
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author | Jing Wu Funa Zhang Haixia Yu Shimei Qi Yu Wu Weihua Xiao |
author_facet | Jing Wu Funa Zhang Haixia Yu Shimei Qi Yu Wu Weihua Xiao |
author_sort | Jing Wu |
collection | DOAJ |
description | Melanin produced by melanocytes protects our skin against ultraviolet (UV) radiation-induced cell damage and oxidative stress. Melanin overproduction by hyperactivated melanocytes is the direct cause of skin hyperpigmentary disorders, such as freckles and melasma. Exploring natural whitening agents without the concern of toxicity has been highly desired. In this study, we focused on a <i>Bifidobacterium longum</i> strain, ZJ1, isolated from a Chinese centenarian, and we evaluated the anti-melanogenic activity of the distinctive extracts of ZJ1. Our results demonstrated that whole lysate (WL) and bacterial lysate (BL) of ZJ1 ferments efficiently reduce α-melanocyte-stimulating hormone (α-MSH)-induced melanin production in B16-F10 cells as well as the melanin content in zebrafish embryos. BL and WL downregulate melanogenesis-related gene expression and indirectly inhibit intracellular tyrosinase activity. Furthermore, they both showed antioxidant activity in a menadione-induced zebrafish embryo model. Our results suggest that ZJ1 fermentation lysates have application potential as therapeutic reagents for hyperpigmentary disorders and whitening agents for cosmetics. |
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spelling | doaj.art-33e8ac5c5bcc460e823f13957a2df2332023-11-19T01:30:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161281010.3390/ijms241612810Anti-Melanogenic and Antioxidant Activity of <i>Bifidobacterium longum</i> Strain ZJ1 Extracts, Isolated from a Chinese CentenarianJing Wu0Funa Zhang1Haixia Yu2Shimei Qi3Yu Wu4Weihua Xiao5The CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, ChinaThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, ChinaInstitute of Advanced Technology, University of Science and Technology of China, Hefei 230094, ChinaInstitute of Advanced Technology, University of Science and Technology of China, Hefei 230094, ChinaThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, ChinaThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, ChinaMelanin produced by melanocytes protects our skin against ultraviolet (UV) radiation-induced cell damage and oxidative stress. Melanin overproduction by hyperactivated melanocytes is the direct cause of skin hyperpigmentary disorders, such as freckles and melasma. Exploring natural whitening agents without the concern of toxicity has been highly desired. In this study, we focused on a <i>Bifidobacterium longum</i> strain, ZJ1, isolated from a Chinese centenarian, and we evaluated the anti-melanogenic activity of the distinctive extracts of ZJ1. Our results demonstrated that whole lysate (WL) and bacterial lysate (BL) of ZJ1 ferments efficiently reduce α-melanocyte-stimulating hormone (α-MSH)-induced melanin production in B16-F10 cells as well as the melanin content in zebrafish embryos. BL and WL downregulate melanogenesis-related gene expression and indirectly inhibit intracellular tyrosinase activity. Furthermore, they both showed antioxidant activity in a menadione-induced zebrafish embryo model. Our results suggest that ZJ1 fermentation lysates have application potential as therapeutic reagents for hyperpigmentary disorders and whitening agents for cosmetics.https://www.mdpi.com/1422-0067/24/16/12810pigmentation<i>Bifidobacterium longum</i>anti-melanogenictyrosinasezebrafishantioxidant |
spellingShingle | Jing Wu Funa Zhang Haixia Yu Shimei Qi Yu Wu Weihua Xiao Anti-Melanogenic and Antioxidant Activity of <i>Bifidobacterium longum</i> Strain ZJ1 Extracts, Isolated from a Chinese Centenarian International Journal of Molecular Sciences pigmentation <i>Bifidobacterium longum</i> anti-melanogenic tyrosinase zebrafish antioxidant |
title | Anti-Melanogenic and Antioxidant Activity of <i>Bifidobacterium longum</i> Strain ZJ1 Extracts, Isolated from a Chinese Centenarian |
title_full | Anti-Melanogenic and Antioxidant Activity of <i>Bifidobacterium longum</i> Strain ZJ1 Extracts, Isolated from a Chinese Centenarian |
title_fullStr | Anti-Melanogenic and Antioxidant Activity of <i>Bifidobacterium longum</i> Strain ZJ1 Extracts, Isolated from a Chinese Centenarian |
title_full_unstemmed | Anti-Melanogenic and Antioxidant Activity of <i>Bifidobacterium longum</i> Strain ZJ1 Extracts, Isolated from a Chinese Centenarian |
title_short | Anti-Melanogenic and Antioxidant Activity of <i>Bifidobacterium longum</i> Strain ZJ1 Extracts, Isolated from a Chinese Centenarian |
title_sort | anti melanogenic and antioxidant activity of i bifidobacterium longum i strain zj1 extracts isolated from a chinese centenarian |
topic | pigmentation <i>Bifidobacterium longum</i> anti-melanogenic tyrosinase zebrafish antioxidant |
url | https://www.mdpi.com/1422-0067/24/16/12810 |
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