Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heteroge...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000800572&lng=en&tlng=en |
| _version_ | 1797713405695492096 |
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| author | Jeziel D Damasceno Gabriel LA Silva Christian Tschudi Luiz RO Tosi |
| author_facet | Jeziel D Damasceno Gabriel LA Silva Christian Tschudi Luiz RO Tosi |
| author_sort | Jeziel D Damasceno |
| collection | DOAJ |
| description | The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes. |
| first_indexed | 2024-03-12T07:36:00Z |
| format | Article |
| id | doaj.art-33e8fb35918a4a43a60d1971184dcba2 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:36:00Z |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-33e8fb35918a4a43a60d1971184dcba22023-09-02T21:28:51ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-8060112857257610.1590/0074-02760170054S0074-02762017000800572Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatidsJeziel D DamascenoGabriel LA SilvaChristian TschudiLuiz RO TosiThe Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000800572&lng=en&tlng=enTERRATrypanosoma brucei telomereLeishmania telomeretelomere transcription |
| spellingShingle | Jeziel D Damasceno Gabriel LA Silva Christian Tschudi Luiz RO Tosi Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids Memorias do Instituto Oswaldo Cruz TERRA Trypanosoma brucei telomere Leishmania telomere telomere transcription |
| title | Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids |
| title_full | Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids |
| title_fullStr | Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids |
| title_full_unstemmed | Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids |
| title_short | Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids |
| title_sort | evidence for regulated expression of telomeric repeat containing rnas terra in parasitic trypanosomatids |
| topic | TERRA Trypanosoma brucei telomere Leishmania telomere telomere transcription |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000800572&lng=en&tlng=en |
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