Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities

Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities

Lung cancer is the leading cause of cancer-related death worldwide. The desmoplastic stroma of lung cancer and other solid tumors is rich in tumor-associated fibroblasts (TAFs) exhibiting an activated/myofibroblast-like phenotype. There is growing awareness that TAFs support key steps of tumor progr...

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Bibliographic Details
Main Authors: Jordi Alcaraz, Rafael Ikemori, Alejandro Llorente, Natalia Díaz-Valdivia, Noemí Reguart, Miguel Vizoso
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
lung cancer
cancer-associated fibroblasts
epigenetics
desmoplasia
TGF-β
smoking
Online Access:https://www.mdpi.com/2072-6694/13/15/3782

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