Optimizing gentamicin conventional and extended interval dosing in neonates using Monte Carlo simulation – a retrospective study

Optimizing gentamicin conventional and extended interval dosing in neonates using Monte Carlo simulation – a retrospective study

Abstract Background Although aminoglycosides are routinely used in neonates, controversy exists regarding empiric dosing regimens. The objectives were to determine gentamicin pharmacokinetics in neonates, and develop initial mg/kg dosing recommendations that optimized target peak and trough concentr...

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Bibliographic Details
Main Authors: Monique Bergenwall, Sandra A. N. Walker, Marion Elligsen, Dolores C. Iaboni, Carla Findlater, Winnie Seto, Eugene Ng
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Pediatrics
Subjects:
Neonate
Gentamicin
Pharmacokinetics
Traditional dosing, extended-interval dosing, Monte Carlo simulation
Online Access:http://link.springer.com/article/10.1186/s12887-019-1676-3

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