DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14<sup>+</sup> CD16<sup>+</sup> CD64<sup>high</sup> CD32<sup>low</sup> Inflammatory Monocytes from Malaria Patients

DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14<sup>+</sup> CD16<sup>+</sup> CD64<sup>high</sup> CD32<sup>low</sup> Inflammatory Monocytes from Malaria Patients

ABSTRACT High levels of circulating immunocomplexes (ICs) are found in patients with either infectious or sterile inflammation. We report that patients with either Plasmodium falciparum or Plasmodium vivax malaria have increased levels of circulating anti-DNA antibodies and ICs containing parasite D...

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Bibliographic Details
Main Authors: Isabella C. Hirako, Carolina Gallego-Marin, Marco A. Ataide, Warrison A. Andrade, Humberto Gravina, Bruno C. Rocha, Rosane B. de Oliveira, Dhelio B. Pereira, Joseph Vinetz, Betty Diamond, Sanjay Ram, Douglas T. Golenbock, Ricardo T. Gazzinelli
Format: Article
Language:English
Published: American Society for Microbiology 2015-12-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01605-15

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