Comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas: A retrospective observation from single-center experience
Background/purpose: Although laparoscopic liver resection (LLR) is a common surgical procedure for hepatocellular carcinoma (HCC), its suitability for large HCCs (≥5 cm) remains controversial. This study compared surgical outcomes of open hepatectomy with LLR for large HCCs. Methods: A total of 313...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Asian Journal of Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958421001779 |
| _version_ | 1819031153766563840 |
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| author | Meng-Hsuan Chiang Kuei-Yen Tsai Hsin-An Chen Wan-Yu Wang Ming-Te Huang |
| author_facet | Meng-Hsuan Chiang Kuei-Yen Tsai Hsin-An Chen Wan-Yu Wang Ming-Te Huang |
| author_sort | Meng-Hsuan Chiang |
| collection | DOAJ |
| description | Background/purpose: Although laparoscopic liver resection (LLR) is a common surgical procedure for hepatocellular carcinoma (HCC), its suitability for large HCCs (≥5 cm) remains controversial. This study compared surgical outcomes of open hepatectomy with LLR for large HCCs. Methods: A total of 313 patients with HCC who underwent hepatectomy between January 2010 and June 2017 were analyzed retrospectively. Demographic data, short-term outcomes, and long-term survivals were analyzed. Results: Among patients with large HCCs (n = 122), the open group (n = 85) had larger tumor sizes (10.91 ± 4.72 vs. 7.45 ± 2.95 cm; p < 0.001) and more advanced stages (stages 3/4: 71.8% vs. 45.9%; p = 0.029) than the LLR group (n = 37), while LLR group achieved less blood loss (623.24 ± 841.75 mL vs. 1091.76 ± 1004.72 mL, p = 0.014) and shorter LOS (9.00 ± 5.13 d vs. 12.82 ± 8.51 d, p = 0.013). There were no significant differences in complication and mortality rates between groups. The 5-year overall and recurrence-free survival rates between the two groups were not significantly different (p = 0.408 and 0.644 respectively). The surgical outcomes showed equal benefit of the two operation types. Conclusion: With sufficient surgeon experience and appropriate patient selection, LLR is a feasible treatment choice for large HCCs. |
| first_indexed | 2024-12-21T06:41:32Z |
| format | Article |
| id | doaj.art-33f0984799044529a1ae6abcdf78369a |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-21T06:41:32Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-33f0984799044529a1ae6abcdf78369a2022-12-21T19:12:42ZengElsevierAsian Journal of Surgery1015-95842021-11-01441113761382Comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas: A retrospective observation from single-center experienceMeng-Hsuan Chiang0Kuei-Yen Tsai1Hsin-An Chen2Wan-Yu Wang3Ming-Te Huang4Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of General Surgery, Department of Surgery, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Corresponding author. No. 291, Zhongzheng Rd.; Zhonghe District, New Taipei City; Taiwan.Background/purpose: Although laparoscopic liver resection (LLR) is a common surgical procedure for hepatocellular carcinoma (HCC), its suitability for large HCCs (≥5 cm) remains controversial. This study compared surgical outcomes of open hepatectomy with LLR for large HCCs. Methods: A total of 313 patients with HCC who underwent hepatectomy between January 2010 and June 2017 were analyzed retrospectively. Demographic data, short-term outcomes, and long-term survivals were analyzed. Results: Among patients with large HCCs (n = 122), the open group (n = 85) had larger tumor sizes (10.91 ± 4.72 vs. 7.45 ± 2.95 cm; p < 0.001) and more advanced stages (stages 3/4: 71.8% vs. 45.9%; p = 0.029) than the LLR group (n = 37), while LLR group achieved less blood loss (623.24 ± 841.75 mL vs. 1091.76 ± 1004.72 mL, p = 0.014) and shorter LOS (9.00 ± 5.13 d vs. 12.82 ± 8.51 d, p = 0.013). There were no significant differences in complication and mortality rates between groups. The 5-year overall and recurrence-free survival rates between the two groups were not significantly different (p = 0.408 and 0.644 respectively). The surgical outcomes showed equal benefit of the two operation types. Conclusion: With sufficient surgeon experience and appropriate patient selection, LLR is a feasible treatment choice for large HCCs.http://www.sciencedirect.com/science/article/pii/S1015958421001779Laparoscopic hepatectomyPrognosisLong-term outcomeOverall survivalRecurrence-free survival |
| spellingShingle | Meng-Hsuan Chiang Kuei-Yen Tsai Hsin-An Chen Wan-Yu Wang Ming-Te Huang Comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas: A retrospective observation from single-center experience Asian Journal of Surgery Laparoscopic hepatectomy Prognosis Long-term outcome Overall survival Recurrence-free survival |
| title | Comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas: A retrospective observation from single-center experience |
| title_full | Comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas: A retrospective observation from single-center experience |
| title_fullStr | Comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas: A retrospective observation from single-center experience |
| title_full_unstemmed | Comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas: A retrospective observation from single-center experience |
| title_short | Comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas: A retrospective observation from single-center experience |
| title_sort | comparison of surgical outcomes for laparoscopic liver resection of large hepatocellular carcinomas a retrospective observation from single center experience |
| topic | Laparoscopic hepatectomy Prognosis Long-term outcome Overall survival Recurrence-free survival |
| url | http://www.sciencedirect.com/science/article/pii/S1015958421001779 |
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