Evaluation of the hemoglobin a1c test in detecting pediatric prediabetes
Aim: It was aimed to evaluate the diagnostic performance of the hemoglobin A1c (HbA1c) test in pediatric prediabetes, and to determine the cut-off value for the adolescent. Material and Method: This study was carried out by retrospectively evaluating the data of 379 adolescents aged between 10 and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Rabia Yılmaz
2023-01-01
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| Series: | Journal of Contemporary Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/2342060 |
| _version_ | 1827980255022809088 |
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| author | Ahmet Esendemir Erdem Çokluk Halil İbrahim Akbay Tuba Batur |
| author_facet | Ahmet Esendemir Erdem Çokluk Halil İbrahim Akbay Tuba Batur |
| author_sort | Ahmet Esendemir |
| collection | DOAJ |
| description | Aim: It was aimed to evaluate the diagnostic performance of the hemoglobin A1c (HbA1c) test in pediatric prediabetes, and to determine the cut-off value for the adolescent.
Material and Method: This study was carried out by retrospectively evaluating the data of 379 adolescents aged between 10 and 18 years. Prediabetes was diagnosed based on glucose criteria, either the fasting glucose value or the 2-hour (2h) glucose value during a 75 g oral glucose tolerance test (OGTT), or HbA1c criteria. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for fasting, OGTT 2h glucose, and HbA1c. The area under the curve (AUC) was calculated for each test by receiver-operating characteristic analysis.
Results: 2.1% of individuals were assigned to the diabetes mellitus group, 21.9% to the prediabetes group, and 76.0% to the normoglycemia group. When 5.7 was used as the threshold value for HbA1c in prediabetes, the sensitivity was 53.0%. The AUC was 0.83 for the HbA1c test. An HbA1c threshold of 5.55% was determined as the optimal cut-off for diagnosing prediabetes, with 62.7% sensitivity and 93.0% specificity.
Conclusion: Although the use of adults’ HbA1c criteria for the diagnosis of prediabetes in the pediatric ages is controversial due to the differences between the results of glucose and HbA1c-based tests, prediabetes screening is still important. HbA1c≥5.55 will be useful to follow up on adolescents with prediabetes in terms of risk and to screen them with blood glucose. |
| first_indexed | 2024-04-09T21:50:37Z |
| format | Article |
| id | doaj.art-33f21fc160fc4d6fa6c770ca75a49ed0 |
| institution | Directory Open Access Journal |
| issn | 2667-7180 |
| language | English |
| last_indexed | 2024-04-09T21:50:37Z |
| publishDate | 2023-01-01 |
| publisher | Rabia Yılmaz |
| record_format | Article |
| series | Journal of Contemporary Medicine |
| spelling | doaj.art-33f21fc160fc4d6fa6c770ca75a49ed02023-03-24T19:43:21ZengRabia YılmazJournal of Contemporary Medicine2667-71802023-01-011311510.16899/jcm.10957861809Evaluation of the hemoglobin a1c test in detecting pediatric prediabetesAhmet Esendemir0Erdem Çokluk1Halil İbrahim Akbay2Tuba Batur3Department of Biochemistry, Kepez State Hospital, AntalyaDepartment of Biochemistry, Faculty of Medicine, Sakarya UniversityDepartment of Biochemistry, Faculty of Medicine, Yüzüncü Yıl University, VanDepartment of Biochemistry, Beyhekim Training and Research Hospital, KonyaAim: It was aimed to evaluate the diagnostic performance of the hemoglobin A1c (HbA1c) test in pediatric prediabetes, and to determine the cut-off value for the adolescent. Material and Method: This study was carried out by retrospectively evaluating the data of 379 adolescents aged between 10 and 18 years. Prediabetes was diagnosed based on glucose criteria, either the fasting glucose value or the 2-hour (2h) glucose value during a 75 g oral glucose tolerance test (OGTT), or HbA1c criteria. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for fasting, OGTT 2h glucose, and HbA1c. The area under the curve (AUC) was calculated for each test by receiver-operating characteristic analysis. Results: 2.1% of individuals were assigned to the diabetes mellitus group, 21.9% to the prediabetes group, and 76.0% to the normoglycemia group. When 5.7 was used as the threshold value for HbA1c in prediabetes, the sensitivity was 53.0%. The AUC was 0.83 for the HbA1c test. An HbA1c threshold of 5.55% was determined as the optimal cut-off for diagnosing prediabetes, with 62.7% sensitivity and 93.0% specificity. Conclusion: Although the use of adults’ HbA1c criteria for the diagnosis of prediabetes in the pediatric ages is controversial due to the differences between the results of glucose and HbA1c-based tests, prediabetes screening is still important. HbA1c≥5.55 will be useful to follow up on adolescents with prediabetes in terms of risk and to screen them with blood glucose.https://dergipark.org.tr/tr/download/article-file/2342060hba1cpediatrik prediyabettanısal performanshba1cpediatric prediabetesdiagnostic performance |
| spellingShingle | Ahmet Esendemir Erdem Çokluk Halil İbrahim Akbay Tuba Batur Evaluation of the hemoglobin a1c test in detecting pediatric prediabetes Journal of Contemporary Medicine hba1c pediatrik prediyabet tanısal performans hba1c pediatric prediabetes diagnostic performance |
| title | Evaluation of the hemoglobin a1c test in detecting pediatric prediabetes |
| title_full | Evaluation of the hemoglobin a1c test in detecting pediatric prediabetes |
| title_fullStr | Evaluation of the hemoglobin a1c test in detecting pediatric prediabetes |
| title_full_unstemmed | Evaluation of the hemoglobin a1c test in detecting pediatric prediabetes |
| title_short | Evaluation of the hemoglobin a1c test in detecting pediatric prediabetes |
| title_sort | evaluation of the hemoglobin a1c test in detecting pediatric prediabetes |
| topic | hba1c pediatrik prediyabet tanısal performans hba1c pediatric prediabetes diagnostic performance |
| url | https://dergipark.org.tr/tr/download/article-file/2342060 |
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