B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

Abstract Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to secrete pathological antibodies, although it is unknown whether this pathway mediates kidney injury. In HHcy-treated 2-kidney, 1-clip (2K1C) hypert...

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Bibliographic Details
Main Authors: Xing Du, Xiaolong Ma, Ying Tan, Fangyu Shao, Chun Li, Yang Zhao, Yutong Miao, Lulu Han, Guohui Dang, Yuwei Song, Dongmin Yang, Zhenling Deng, Yue Wang, Changtao Jiang, Wei Kong, Juan Feng, Xian Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01313-x

Internet

https://doi.org/10.1038/s41392-023-01313-x

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