Plasma UCHL1, GFAP, Tau, and NfL Are Not Different in Young Healthy Persons With Mild COVID-19 Symptoms Early in the Pandemic: A Pilot Study
Elevated levels of brain injury biomarkers have been found primarily in middle-aged or older persons experiencing moderate-to-severe COVID-19 symptoms. However, there is little research in young adults, and there is concern that COVID-19 causes brain injury even in the absence of moderate-to-severe...
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2023-05-01
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| Series: | Neurotrauma Reports |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/NEUR.2023.0014 |
| _version_ | 1797346150110461952 |
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| author | Matthew J. Rogatzki Rachel E. Szeghy Nina L. Stute Valesha M. Province Marc A. Augenreich Jonathon L. Stickford Abigail S.L. Stickford Erik D. Hanson Stephen M. Ratchford |
| author_facet | Matthew J. Rogatzki Rachel E. Szeghy Nina L. Stute Valesha M. Province Marc A. Augenreich Jonathon L. Stickford Abigail S.L. Stickford Erik D. Hanson Stephen M. Ratchford |
| author_sort | Matthew J. Rogatzki |
| collection | DOAJ |
| description | Elevated levels of brain injury biomarkers have been found primarily in middle-aged or older persons experiencing moderate-to-severe COVID-19 symptoms. However, there is little research in young adults, and there is concern that COVID-19 causes brain injury even in the absence of moderate-to-severe symptoms. Therefore, the purpose of our study was to investigate whether neurofilament light (NfL), glial fibrillary acidic protein (GFAP), tau, or ubiquitin carboxyl-terminal esterase L1 (UCHL1) are elevated in the plasma of young adults with mild COVID-19 symptoms. Twelve participants diagnosed with COVID-19 had plasma collected 1, 2, 3, and 4 months after diagnosis to determine whether NfL, GFAP, tau, and UCHL1 concentrations increased over time or whether plasma concentrations were elevated compared with COVID-19-na?ve participants. We also compared plasma NfL, GFAP, tau, and UCHL1 concentrations between sexes. Our results showed no difference between NfL, GFAP, tau, and UCHL1 concentrations in COVID-19-na?ve participants and COVID-19-positive participants at any of the four time points (p?=?0.771). Within the COVID-19-positive participants, UCHL1 levels were higher at month 3 after diagnosis compared to month 1 or month 2 (p?=?0.027). Between sexes, females were found to have higher UCHL1 (p?=?0.003) and NfL (p?=?0.037) plasma concentrations compared to males, whereas males had higher plasma tau concentrations than females (p?=?0.024). Based on our data, it appears that mild COVID-19 in young adults does not increase plasma NfL, GFAP, tau, or UCHL1. |
| first_indexed | 2024-03-08T11:28:50Z |
| format | Article |
| id | doaj.art-33f44b4652314f57aafa82363bcd032e |
| institution | Directory Open Access Journal |
| issn | 2689-288X |
| language | English |
| last_indexed | 2024-03-08T11:28:50Z |
| publishDate | 2023-05-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj.art-33f44b4652314f57aafa82363bcd032e2024-01-26T04:38:59ZengMary Ann LiebertNeurotrauma Reports2689-288X2023-05-014133034110.1089/NEUR.2023.0014Plasma UCHL1, GFAP, Tau, and NfL Are Not Different in Young Healthy Persons With Mild COVID-19 Symptoms Early in the Pandemic: A Pilot StudyMatthew J. RogatzkiRachel E. SzeghyNina L. StuteValesha M. ProvinceMarc A. AugenreichJonathon L. StickfordAbigail S.L. StickfordErik D. HansonStephen M. RatchfordElevated levels of brain injury biomarkers have been found primarily in middle-aged or older persons experiencing moderate-to-severe COVID-19 symptoms. However, there is little research in young adults, and there is concern that COVID-19 causes brain injury even in the absence of moderate-to-severe symptoms. Therefore, the purpose of our study was to investigate whether neurofilament light (NfL), glial fibrillary acidic protein (GFAP), tau, or ubiquitin carboxyl-terminal esterase L1 (UCHL1) are elevated in the plasma of young adults with mild COVID-19 symptoms. Twelve participants diagnosed with COVID-19 had plasma collected 1, 2, 3, and 4 months after diagnosis to determine whether NfL, GFAP, tau, and UCHL1 concentrations increased over time or whether plasma concentrations were elevated compared with COVID-19-na?ve participants. We also compared plasma NfL, GFAP, tau, and UCHL1 concentrations between sexes. Our results showed no difference between NfL, GFAP, tau, and UCHL1 concentrations in COVID-19-na?ve participants and COVID-19-positive participants at any of the four time points (p?=?0.771). Within the COVID-19-positive participants, UCHL1 levels were higher at month 3 after diagnosis compared to month 1 or month 2 (p?=?0.027). Between sexes, females were found to have higher UCHL1 (p?=?0.003) and NfL (p?=?0.037) plasma concentrations compared to males, whereas males had higher plasma tau concentrations than females (p?=?0.024). Based on our data, it appears that mild COVID-19 in young adults does not increase plasma NfL, GFAP, tau, or UCHL1.https://www.liebertpub.com/doi/full/10.1089/NEUR.2023.0014biomarkersCOVID-19GFAPmild symptomsNfLplasma |
| spellingShingle | Matthew J. Rogatzki Rachel E. Szeghy Nina L. Stute Valesha M. Province Marc A. Augenreich Jonathon L. Stickford Abigail S.L. Stickford Erik D. Hanson Stephen M. Ratchford Plasma UCHL1, GFAP, Tau, and NfL Are Not Different in Young Healthy Persons With Mild COVID-19 Symptoms Early in the Pandemic: A Pilot Study Neurotrauma Reports biomarkers COVID-19 GFAP mild symptoms NfL plasma |
| title | Plasma UCHL1, GFAP, Tau, and NfL Are Not Different in Young Healthy Persons With Mild COVID-19 Symptoms Early in the Pandemic: A Pilot Study |
| title_full | Plasma UCHL1, GFAP, Tau, and NfL Are Not Different in Young Healthy Persons With Mild COVID-19 Symptoms Early in the Pandemic: A Pilot Study |
| title_fullStr | Plasma UCHL1, GFAP, Tau, and NfL Are Not Different in Young Healthy Persons With Mild COVID-19 Symptoms Early in the Pandemic: A Pilot Study |
| title_full_unstemmed | Plasma UCHL1, GFAP, Tau, and NfL Are Not Different in Young Healthy Persons With Mild COVID-19 Symptoms Early in the Pandemic: A Pilot Study |
| title_short | Plasma UCHL1, GFAP, Tau, and NfL Are Not Different in Young Healthy Persons With Mild COVID-19 Symptoms Early in the Pandemic: A Pilot Study |
| title_sort | plasma uchl1 gfap tau and nfl are not different in young healthy persons with mild covid 19 symptoms early in the pandemic a pilot study |
| topic | biomarkers COVID-19 GFAP mild symptoms NfL plasma |
| url | https://www.liebertpub.com/doi/full/10.1089/NEUR.2023.0014 |
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