Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) is the most frequent form of lung cancer and represents a set of histological entities that have an ominous long-term prognosis, for example, adenocarcinoma, squamous carcinoma and large cell carcinoma. Both small cell and non-small cell lung cancer are the main ca...
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| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/2/167 |
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| author | Miguel A. Ortega Leonel Pekarek Fátima Navarro Oscar Fraile-Martínez Cielo García-Montero Miguel Ángel Álvarez-Mon Raúl Diez-Pedrero María del Carmen Boyano-Adánez Luis G. Guijarro Silvestra Barrena-Blázquez Ana M. Gómez-Lahoz Sergio Haro Mónica Arroyo Jorge Monserrat Miguel A. Saez Melchor Alvarez-Mon |
| author_facet | Miguel A. Ortega Leonel Pekarek Fátima Navarro Oscar Fraile-Martínez Cielo García-Montero Miguel Ángel Álvarez-Mon Raúl Diez-Pedrero María del Carmen Boyano-Adánez Luis G. Guijarro Silvestra Barrena-Blázquez Ana M. Gómez-Lahoz Sergio Haro Mónica Arroyo Jorge Monserrat Miguel A. Saez Melchor Alvarez-Mon |
| author_sort | Miguel A. Ortega |
| collection | DOAJ |
| description | Non-small cell lung cancer (NSCLC) is the most frequent form of lung cancer and represents a set of histological entities that have an ominous long-term prognosis, for example, adenocarcinoma, squamous carcinoma and large cell carcinoma. Both small cell and non-small cell lung cancer are the main causes of oncological death and the oncological diseases with the highest incidence worldwide. With regard to clinical approaches for NSCLC, several advances have been achieved in diagnosis and treatment; the analysis of different molecular markers has led to the development of new targeted therapies that have improved the prognosis for selected patients. Despite this, most patients are diagnosed in an advanced stage, presenting a limited life expectancy with an ominous short-term prognosis. Numerous molecular alterations have been described in recent years, allowing for the development of therapies directed against specific therapeutic targets. The correct identification of the expression of different molecular markers has allowed for the individualization of treatment throughout the disease course, expanding the available therapeutic arsenal. The purpose of this article is to summarize the main characteristics of NSCLC and the advances that have occurred in the use of targeted therapies, thus explaining the limitations that have been observed in the management of this disease. |
| first_indexed | 2024-03-11T08:34:22Z |
| format | Article |
| id | doaj.art-33f4a7403b1444d7b862178fdfcca4b4 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T08:34:22Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-33f4a7403b1444d7b862178fdfcca4b42023-11-16T21:31:40ZengMDPI AGJournal of Personalized Medicine2075-44262023-01-0113216710.3390/jpm13020167Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung CancerMiguel A. Ortega0Leonel Pekarek1Fátima Navarro2Oscar Fraile-Martínez3Cielo García-Montero4Miguel Ángel Álvarez-Mon5Raúl Diez-Pedrero6María del Carmen Boyano-Adánez7Luis G. Guijarro8Silvestra Barrena-Blázquez9Ana M. Gómez-Lahoz10Sergio Haro11Mónica Arroyo12Jorge Monserrat13Miguel A. Saez14Melchor Alvarez-Mon15Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of General and Digestive Surgery, General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Alcalá de Henares, SpainUnit of Biochemistry and Molecular Biology, Department of Systems Biology, University of Alcalá, 28871 Alcalá de Henares, SpainRamon and Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, SpainDepartment of General and Digestive Surgery, General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, SpainNon-small cell lung cancer (NSCLC) is the most frequent form of lung cancer and represents a set of histological entities that have an ominous long-term prognosis, for example, adenocarcinoma, squamous carcinoma and large cell carcinoma. Both small cell and non-small cell lung cancer are the main causes of oncological death and the oncological diseases with the highest incidence worldwide. With regard to clinical approaches for NSCLC, several advances have been achieved in diagnosis and treatment; the analysis of different molecular markers has led to the development of new targeted therapies that have improved the prognosis for selected patients. Despite this, most patients are diagnosed in an advanced stage, presenting a limited life expectancy with an ominous short-term prognosis. Numerous molecular alterations have been described in recent years, allowing for the development of therapies directed against specific therapeutic targets. The correct identification of the expression of different molecular markers has allowed for the individualization of treatment throughout the disease course, expanding the available therapeutic arsenal. The purpose of this article is to summarize the main characteristics of NSCLC and the advances that have occurred in the use of targeted therapies, thus explaining the limitations that have been observed in the management of this disease.https://www.mdpi.com/2075-4426/13/2/167non-small cell lung carcinomalung adenocarcinomapulmonary squamous cell carcinomalarge cell carcinomaimmunotherapy |
| spellingShingle | Miguel A. Ortega Leonel Pekarek Fátima Navarro Oscar Fraile-Martínez Cielo García-Montero Miguel Ángel Álvarez-Mon Raúl Diez-Pedrero María del Carmen Boyano-Adánez Luis G. Guijarro Silvestra Barrena-Blázquez Ana M. Gómez-Lahoz Sergio Haro Mónica Arroyo Jorge Monserrat Miguel A. Saez Melchor Alvarez-Mon Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer Journal of Personalized Medicine non-small cell lung carcinoma lung adenocarcinoma pulmonary squamous cell carcinoma large cell carcinoma immunotherapy |
| title | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
| title_full | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
| title_fullStr | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
| title_full_unstemmed | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
| title_short | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
| title_sort | updated views in targeted therapy in the patient with non small cell lung cancer |
| topic | non-small cell lung carcinoma lung adenocarcinoma pulmonary squamous cell carcinoma large cell carcinoma immunotherapy |
| url | https://www.mdpi.com/2075-4426/13/2/167 |
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