Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene
The RECK gene was initially isolated as a transformation suppressor gene encoding a novel membrane-anchored glycoprotein and later found to suppress tumor invasion and metastasis by regulating matrix metalloproteinase-9. Its expression is ubiquitous in normal tissues, but undetectable in many tumor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1999-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700014 |
| _version_ | 1798043947784732672 |
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| author | Sasahara R.M. Takahashi C. Sogayar M.C. Noda M. |
| author_facet | Sasahara R.M. Takahashi C. Sogayar M.C. Noda M. |
| author_sort | Sasahara R.M. |
| collection | DOAJ |
| description | The RECK gene was initially isolated as a transformation suppressor gene encoding a novel membrane-anchored glycoprotein and later found to suppress tumor invasion and metastasis by regulating matrix metalloproteinase-9. Its expression is ubiquitous in normal tissues, but undetectable in many tumor cell lines and in fibroblastic lines transformed by various oncogenes. The RECK gene promoter has been cloned and characterized. One of the elements responsible for the oncogene-mediated downregulation of mouse RECK gene is the Sp1 site, where the Sp1 and Sp3 factors bind. Sp1 transcription factor family is involved in the basal level of promoter activity of many genes, as well as in dynamic regulation of gene expression; in a majority of cases as a positive regulator, or, as exemplified by the oncogene-mediated suppression of RECK gene expression, as a negative transcription regulator. The molecular mechanisms of the downregulation of mouse RECK gene and other tumor suppressor genes are just beginning to be uncovered. Understanding the regulation of these genes may help to develop strategies to restore their expression in tumor cells and, hence, suppress the cells' malignant behavior. |
| first_indexed | 2024-04-11T22:56:07Z |
| format | Article |
| id | doaj.art-33f524828a1d4c5bbabe201ddc811d7e |
| institution | Directory Open Access Journal |
| issn | 0100-879X 0034-7310 |
| language | English |
| last_indexed | 2024-04-11T22:56:07Z |
| publishDate | 1999-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-33f524828a1d4c5bbabe201ddc811d7e2022-12-22T03:58:23ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73101999-01-01327891895Oncogene-mediated downregulation of RECK, a novel transformation suppressor geneSasahara R.M.Takahashi C.Sogayar M.C.Noda M.The RECK gene was initially isolated as a transformation suppressor gene encoding a novel membrane-anchored glycoprotein and later found to suppress tumor invasion and metastasis by regulating matrix metalloproteinase-9. Its expression is ubiquitous in normal tissues, but undetectable in many tumor cell lines and in fibroblastic lines transformed by various oncogenes. The RECK gene promoter has been cloned and characterized. One of the elements responsible for the oncogene-mediated downregulation of mouse RECK gene is the Sp1 site, where the Sp1 and Sp3 factors bind. Sp1 transcription factor family is involved in the basal level of promoter activity of many genes, as well as in dynamic regulation of gene expression; in a majority of cases as a positive regulator, or, as exemplified by the oncogene-mediated suppression of RECK gene expression, as a negative transcription regulator. The molecular mechanisms of the downregulation of mouse RECK gene and other tumor suppressor genes are just beginning to be uncovered. Understanding the regulation of these genes may help to develop strategies to restore their expression in tumor cells and, hence, suppress the cells' malignant behavior.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700014RECK transformation suppressor genereversiontranscriptional regulationSp1 familytumor suppressor genes |
| spellingShingle | Sasahara R.M. Takahashi C. Sogayar M.C. Noda M. Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene Brazilian Journal of Medical and Biological Research RECK transformation suppressor gene reversion transcriptional regulation Sp1 family tumor suppressor genes |
| title | Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene |
| title_full | Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene |
| title_fullStr | Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene |
| title_full_unstemmed | Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene |
| title_short | Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene |
| title_sort | oncogene mediated downregulation of reck a novel transformation suppressor gene |
| topic | RECK transformation suppressor gene reversion transcriptional regulation Sp1 family tumor suppressor genes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700014 |
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