Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways

Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways

We reported recently that sphingosine-1-phosphate (S1P) is a novel regulator of aldosterone secretion in zona glomerulosa cells of adrenal glands and that phospholipase D (PLD) is implicated in this process. We now show that S1P causes the phosphorylation of protein kinase B (PKB) and extracellularl...

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Bibliographic Details
Main Authors: Leyre Brizuela, Miriam Rábano, Patricia Gangoiti, Natalia Narbona, José María Macarulla, Miguel Trueba, Antonio Gómez-Muñoz
Format: Article
Language:English
Published: Elsevier 2007-10-01
Series:Journal of Lipid Research
Subjects:
adrenal gland
ceramide
mitogen-activated protein kinase
glomerulosa cells
mineralocorticoids
phospholipase D
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520424708

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http://www.sciencedirect.com/science/article/pii/S0022227520424708

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